J. J. Coon

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.

Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15

The paper identifies TFEB regulation of BMP lipid catabolism via Pla2g15, showing increased BMP lipids in Pla2g15 knockout mice and cold intolerance upon TFEB knockdown.

A role for cytoglobin in regulating intracellular hydrogen peroxide and redox signals in the vasculature

This study shows cytoglobin regulates intracellular hydrogen peroxide and redox signals by reducing hyperoxidation of peroxiredoxins and facilitating Hyper7 reduction, independent of heme-based hydrogen peroxide reactions.

An alphacoronavirus polymerase structure reveals conserved co-factor functions

This paper determines the structure of an alphacoronavirus polymerase complex and identifies conserved cofactor interactions important for antiviral drug development.

Hem25p is a mitochondrial IPP transporter

The paper identifies Hem25p as a mitochondrial IPP transporter in yeast, essential for CoQ biosynthesis.

Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

This study shows that Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy, leading to metabolic defects and early lethality in mice.

Molecular anatomy of eosinophil activation by IL5 and IL33

This study identifies common and distinct phosphoproteomic effects of IL5 and IL33 on human eosinophils, revealing pathways involved in cytoskeletal reorganization, adhesion, and transcriptional regulation.

Structure and functionality of a multimeric human COQ7:COQ9 complex

The paper presents the structure and functional analysis of a multimeric COQ7:COQ9 complex involved in CoQ biosynthesis, revealing its mechanism for accessing hydrophobic precursors and coordinating CoQ synthesis.

Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states

This study identifies a shared neutrophil activation signature between severe COVID-19 and other acute inflammatory conditions, suggesting common therapeutic targets.

UbiB proteins regulate cellular CoQ distribution

This study identifies two mitochondrial proteins, Cqd1 and Cqd2, that regulate CoQ distribution and oxidative stress resistance in yeast.

Phosphorylation controls RNA binding and transcription by the influenza virus polymerase

This study identifies phosphorylation sites in the influenza virus polymerase that regulate its activity and virus replication by affecting RNA binding and transcription.

Heterologous glycosyl hydrolase expression and cellular reprogramming resembling sucrose-induction enable Zymomonas mobilis growth on cellobiose

This study reprograms Zymomonas mobilis to grow on cellobiose by expressing a heterologous glycosyl hydrolase and adapting it to sucrose-induced cellular changes, achieving 50% cellobiose conversion to glucose within 24 hours.

Broad and thematic remodeling of the surface glycoproteome on isogenic cells transformed with driving proliferative oncogenes

This study uses proteomics to show how six oncogenes remodel the surface glycoproteome of breast cells, with common functional themes reversed by MEK inhibition.

Real time health monitoring through urine metabolomics

This paper explores using urine metabolomics to monitor health in real time through a smartphone app and discusses initial findings from two healthy subjects.

Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

This study shows that Pptc7 is essential for mitochondrial metabolism and biogenesis, as its deletion in mice causes metabolic defects and early death.

Chemical genomic guided engineering of gamma-valerolactone tolerant yeast

The paper engineers a GVL-tolerant yeast strain by deleting PAD1 and FDC1, enhancing ergosterol content and improving fermentation in GVL-containing hydrolysates.

Yeast de novo genes preferentially emerge from divergently transcribed, GC-rich intergenic regions

The paper identifies 703 de novo genes in 15 yeast species and finds they preferentially arise from GC-rich intergenic regions near divergent promoters and recombination hotspots.

Post-Transcriptional Control of Coenzyme Q Biosynthesis Revealed by Transomic Analysis of the RNA-Binding Protein Puf3p

This study identifies Puf3p as a regulator of CoQ biosynthesis through transomic analysis, revealing its role in controlling Coq5p levels and mitochondrial biogenesis.

The dental calculus metabolome in modern and historic samples

This study characterizes the metabolome of modern and historic dental calculus to identify patterns of metabolite persistence and loss over time.

Inhibition of microbial biofuel production in drought stressed switchgrass hydrolysate

This study investigates how drought stress in switchgrass affects biofuel production by inhibiting yeast fermentation due to the formation of toxic compounds during pretreatment.