Author

S. C. Dentro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. Gerstung· 4 shared J. Demeulemeester· 3 shared C. Jolly· 2 shared D. G. Livitz· 2 shared D. Rosebrock· 2 shared F. Markowetz· 2 shared G. Getz· 2 shared G. Macintyre· 2 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

M. Gerstung

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Notch1 mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth

E. Abby, S. C. Dentro, M. W. J. Hall, J. C. Fowler, S. H. Ong, R. Sood, C. W. Siebel, M. Gerstung, B. A. Hall, P. Jones

The paper shows NOTCH1 mutations promote clonal expansion in normal esophageal epithelium but hinder tumor growth, suggesting NOTCH1 inhibition could prevent esophageal squamous cancer.

bioRxiv · Jun 18, 2021 · PreprintCancer Biology

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

S. C. Dentro, I. Leshchiner, K. Haase, M. Tarabichi, J. Wintersinger, A. G. Deshwar, K. Yu, Y. Rubanova, G. Macintyre, J. Demeulemeester, I. Vazquez-Garcia, K. Kleinheinz, D. G. Livitz, S. Malikic, N. Donmez, , Q. D. Morris

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.

Cell · Apr 1, 2021Peer-reviewedCancer Biology

Biallelic mutations in cancer genomes reveal local mutational determinants

J. Demeulemeester, S. C. Dentro, M. Gerstung, P. Van Loo

The paper identifies biallelic mutations in cancer genomes and highlights their implications for mutation hotspots and variant calling.

bioRxiv · Mar 29, 2021Cancer Biology

The evolutionary history of 2,658 cancers

M. Gerstung, C. Jolly, I. Leshchiner, S. C. Dentro, S. Gonzalez Rosado, D. Rosebrock, T. J. Mitchell, Y. Rubanova, P. Anur, K. Yu, M. Tarabichi, A. Deshwar, J. Wintersinger, K. Kleinheinz, I. Vazquez-Garcia, , Spellman

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.

bioRxiv · Sep 12, 2018Cancer Biology