S. H. Ong

Epithelioids: Self-sustaining 3D epithelial cultures to study long-term processes

This paper introduces epithelioids, a 3D culture system for mouse and human epithelia that maintains structure and function over long periods, enabling study of long-term biological processes.

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

This study shows p53 mutations in normal esophagus drive clonal expansion but are constrained by clonal competition, and LOH is critical for malignant transformation.

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

The paper shows that mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors through cell competition, preventing tumor formation.

Notch1 mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth

The paper shows NOTCH1 mutations promote clonal expansion in normal esophageal epithelium but hinder tumor growth, suggesting NOTCH1 inhibition could prevent esophageal squamous cancer.

Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus

The paper shows that reducing aerobic glycolysis differences between mutant and wild-type cells limits the competitive advantage of PIK3CA mutant progenitors in the esophagus.

KAT7 is a therapeutic vulnerability of MLL-rearranged acute myeloid leukemia

This study identifies KAT7 as a critical therapeutic target in MLL-rearranged AML by showing its role in maintaining acetylation marks and supporting cell proliferation.