Author

S. A. Hirota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

K. L. Flannigan· 2 shared A. Beck· 1 shared A. Chandran· 1 shared A. Matson· 1 shared A. Mohamud· 1 shared A. P. Naren· 1 shared A. Schon· 1 shared A. Vrzalova· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

K. L. Flannigan

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Author profile →

2 papers

Recent·Most cited

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

Z. Dvorak, F. Felix Kopp, C. M. Costello, J. S. Kemp, H. Li, A. Vrzalova, M. Stepankova, I. Iveta Bartonkov, K. Poulikova, B. Vyhlidalova, L. U. Nordstroem, C. Karunaratne, H. Ranhotra, K. S. Mun, A. P. Naren, , R. B. Sartor

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

bioRxiv · Jan 3, 2020Biochemistry

Vancomycin Relieves Mycophenolate Mofetil-Induced Gastrointestinal Toxicity by Eliminating Gut Bacterial β-Glucuronidase Activity

M. R. Taylor, K. L. Flannigan, H. Rahim, A. Mohamud, I. A. Lewis, S. A. Hirota, S. C. Greenway

This study shows vancomycin reduces MMF-induced GI toxicity by inhibiting gut bacterial β-glucuronidase activity, preventing MPA conversion from its glucuronidated form.

bioRxiv · Feb 26, 2019Microbiology