I. A. Lewis

SCALiR: a web application for automating absolute quantification of mass spectrometry-based metabolomics data

SCALiR automates absolute quantification of metabolomics data using LC-MS, achieving high correlation and reproducibility with minimal user input.

Method for quantifying the metabolic boundary fluxes of cell cultures in large cohorts by high resolution hydrophilic liquid chromatography mass spectrometry

The paper introduces a method to quantify metabolic boundary fluxes in large microbial cohorts using high-resolution hydrophilic liquid chromatography mass spectrometry.

Altered glutamine metabolism of cultured fibroblasts predicts severity of cardiac dysfunction in the dilated cardiomyopathy with ataxia syndrome (DCMA), a mitochondrial cardiomyopathy

The paper identifies altered glutamine and lactate metabolism in DCMA patient fibroblasts as a predictor of cardiac dysfunction severity.

PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide-dependent biofilm formation

The paper identifies PelX as a UDP-GlcNAc C4-epimerase essential for Pel polysaccharide synthesis and biofilm formation in Pseudomonas protegens.

Thermogenic hydrocarbons fuel a redox stratified subseafloor microbiome in deep sea cold seep sediments

This study profiles microbial activities in deep sea cold seep sediments, revealing hydrocarbon oxidation pathways and their role in sustaining diverse microbial communities across redox gradients.

Vancomycin Relieves Mycophenolate Mofetil-Induced Gastrointestinal Toxicity by Eliminating Gut Bacterial β-Glucuronidase Activity

This study shows vancomycin reduces MMF-induced GI toxicity by inhibiting gut bacterial β-glucuronidase activity, preventing MPA conversion from its glucuronidated form.

Metabolic potential of uncultured bacteria and archaea associated with petroleum seepage in deep-sea sediments

This study investigates microbial energy and carbon acquisition strategies in deep-sea petroleum seeps using metagenomic analysis and geochemical data.