WNT6-ACC2-induced accumulation of triacylglycerol rich lipid droplets is exploited by Mycobacterium tuberculosis
J. Brandenburg, S. Marwitz, S. C. Tazoll, F. Waldow, B. Kalsdorf, T. Vierbuchen, T. Scholzen, A. Gross, S. Goldenbaum, A. Hoelscher, M. Hein, L. Linnemann, M. Reimann, A. Kispert, M. Leitges, , N. Reiling
This study shows that the WNT6-ACC2 pathway promotes lipid droplet accumulation in macrophages, which Mycobacterium tuberculosis exploits for growth, and that inhibiting this pathway enhances anti-tuberculosis treatment.
bioRxiv · Jun 26, 2020 · PreprintImmunology