A. Gross

Up-regulated transcriptional regulators in mutant RAS gene signatures: a time-resolved multi-omics study in generic epithelial cell models

This study identifies HMGA2 as a master regulator of mutant RAS-driven gene expression by analyzing time-resolved transcriptome and proteome changes in epithelial cells.

High-energy demand and nutrient exhaustion in MTCH2 knockout cells

This study shows that MTCH2 deletion increases energy demand and metabolic imbalance in cells, which inhibits adipocyte differentiation.

Deciphering Cell-types and Gene Signatures Associated with Disease Activity in Rheumatoid Arthritis using Single Cell RNA-sequencing

This study uses single-cell RNA sequencing of PBMCs from RA patients and controls to identify disease-associated cell subsets and gene signatures linked to RA disease activity.

Diversity loss in microbial ecosystems undergoing gradual environmental changes

This study models how gradual environmental changes impact microbial ecosystems, showing that diversity loss leads to slowed dynamics and potential response lags in diverse ecosystems.

A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy

The paper shows Pho81 modulates pexophagy by interacting with Atg11 at the AKC during phosphate starvation, compensating for inactive Atg13 and conveying metabolic signals.

MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion

This study identifies cooperative mechanisms between MTCH2, MFN2, and lysophosphatidic acid synthesis in sustaining mitochondrial fusion.

Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation

The paper identifies UBE2H-CTLH ubiquitylation modules that regulate stages of human erythropoiesis, showing their role in controlling maturation and heme synthesis.

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in Glioma

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

WNT6-ACC2-induced accumulation of triacylglycerol rich lipid droplets is exploited by Mycobacterium tuberculosis

This study shows that the WNT6-ACC2 pathway promotes lipid droplet accumulation in macrophages, which Mycobacterium tuberculosis exploits for growth, and that inhibiting this pathway enhances anti-tuberculosis treatment.