S. Covarrubias

Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response

This study identifies VILMIR, a novel lncRNA upregulated by respiratory viral infections and IFN-β, which modulates the host interferon response.

CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation epigenetically and inflammatory signaling through a short, encoded peptide

The paper uses CRISPRi screens to identify the lncRNA LOUP as a regulator of macrophage differentiation and inflammatory signaling through epigenetic and peptide-mediated mechanisms.

Inflammation Drives Alternative First Exon usage to Regulate Immune Genes including a Novel Iron Regulated Isoform of Aim2

The paper identifies inflammation-induced alternative first exon usage in immune genes, revealing a novel iron-regulated Aim2 isoform with a 5′UTR iron-responsive element.

Generation and utilization of a HEK-293T murine GM-CSF expressing cell line

The paper generates a HEK-293T cell line expressing murine GM-CSF and shows it supports dendritic cell and alveolar macrophage differentiation as an alternative to commercial GM-CSF.

High throughput CRISPR screening identifies genes involved in macrophage viability and inflammatory pathways

The paper uses CRISPR screening to identify genes essential for macrophage viability and regulators of inflammatory pathways like NF-κB and TNF signaling.