A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models
M. Puray-Chavez, J. E. Eschbach, M. Xia, K. LaPak, Q. Zhou, R. Jasuja, J. Pan, J. Xu, Z. Zhou, S. Mohammed, Q. Wang, D. Lawson, S. Djokic, G. Hou, S. Ding, , S. B. Kutluay
This study identifies tonic activation of the cGAS-STING and IFN pathways in ACE2-positive airway cells as a factor limiting SARS-CoV-2 replication.
bioRxiv · Jan 7, 2024Microbiology