J. E. Eschbach

A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

This study identifies tonic activation of the cGAS-STING and IFN pathways in ACE2-positive airway cells as a factor limiting SARS-CoV-2 replication.

Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA

This study identifies compensatory mutations that restore HIV-1 integrase-gRNA binding and infectivity, revealing the role of electrostatic interactions in this process and their impact on allosteric inhibitor sensitivity.

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

This study identifies H522 cells as ACE2-negative human cells permissive to SARS-CoV-2 infection, revealing alternative receptor usage and host response mechanisms.

Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection

This study shows that destabilizing the HIV-1 capsid lattice leads to premature loss of the viral genome and integrase enzyme in infected cells.

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

This study identifies three mechanisms by which class II HIV-1 integrase substitutions disrupt IN-RNA interactions, leading to virion maturation defects and premature viral genome degradation.