Author

S. G. Dakin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:differential expression· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Approach:experimental assay· 2

Frequent Co-Authors

A. J. Carr· 5 shared B. Watkins· 3 shared K. Wheway· 3 shared A. H. Taylor· 2 shared B. Usukhbayar· 2 shared D. Beazley· 2 shared J. Rees· 2 shared M. A. Salazar· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersCancer Biology

A. J. Carr

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Author profile →

5 papers

Recent·Most cited

Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

N. A. Jakobsen, S. Turkalj, A. G. X. Zeng, B. Stoilova, M. Metzner, M. S. Nagree, S. Shah, R. Moore, B. Usukhbayar, M. A. Salazar, G.-A. Gafencu, A. Kennedy, S. Newman, B. J. L. Kendrick, A. H. Taylor, , P. Vyas

This study identifies how DNMT3A and TET2 mutations in hematopoietic stem cells confer a selective advantage by reducing inflammation and aging effects.

bioRxiv · Sep 12, 2023 · PreprintCancer Biology

Primed to resolve: A single cell atlas of the shoulder capsule reveals a cellular basis for resolving inflammatory fibrosis

M. T. Ng, R. Borst, H. Gacaferi, S. Davidson, C. C. Machado, I. Reekie, M. Attar, D. Windell, M. Kurowska-Stolarska, L. MacDonald, S. Alivernini, M. Garvilles, K. Jansen, A. Bhalla, A. Lee, , S. G. Dakin

This study identifies MERTK+ macrophages and fibroblasts involved in resolving fibrosis in frozen shoulder using single-cell analysis and suggests therapeutic strategies to enhance their interaction.

bioRxiv · Jan 16, 2023 · PreprintCell Biology

Detecting and quantifying clonal selection in somatic stem cells

V. Korber, N. Ansari-Pour, N. A. Jakobsen, R. Moore, N. Claudino, M. Metzner, F. Horsch, B. Usukhbayar, M. A. Salazar, S. Newman, B. J. Kendrick, A. H. Taylor, R. Afinowi-Luitz, R. Gundle, B. Watkins, , T. Hofer

This study introduces SCIFER, a method to detect and quantify clonal selection in somatic stem cells, revealing accelerated stem cell division in clonal hematopoiesis.

bioRxiv · Dec 15, 2021Cancer Biology

Interleukin-17A causes osteoarthritis-like transcriptional changes in human osteoarthritis-derived chondrocytes and synovial fibroblasts in vitro

J. Y. Mimpen, M. J. Baldwin, A. P. Cribbs, M. Philpott, A. J. Carr, S. G. Dakin, S. J. B. Snelling

This study shows IL-17A induces OA-like gene expression in OA-derived chondrocytes and synovial fibroblasts, with secukinumab inhibiting these effects.

bioRxiv · Mar 5, 2021Immunology

Proresolving mediators LXB4 and RvE1 regulate inflammation in stromal cells from patients with shoulder tendon tears

S. G. Dakin, R. A. Colas, K. Wheway, B. Watkins, L. Appleton, J. Rees, S. Gwilym, C. Little, J. Dalli, A. J. Carr

This study shows that proresolving mediators LXB4 and RvE1 modulate inflammation in tendon stromal cells from patients with shoulder tendon tears by altering lipid mediator profiles and inflammatory markers.

bioRxiv · Apr 11, 2019Cell Biology