Author

S. Gadde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Cote· 3 shared E. Durocher· 2 shared M. D. Fullerton· 2 shared N. D. LeBlond· 2 shared A. Popatia· 1 shared B. E. Kemp· 1 shared E. Farah· 1 shared E. Gahunia· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBioengineering

M. Cote

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Development of 3-in-1 nanotherapeutic strategies for ovarian cancer

E. Durocher, S. McGrath, E. Gahunia, N. Matsuura, S. Gadde

This paper develops a 3-in-1 nanotherapeutic approach combining cisplatin, olaparib, and metformin for ovarian cancer, showing stability and enhanced therapeutic effects in vitro.

bioRxiv · Jul 17, 2024 · PreprintBioengineering

Nanoparticles co-delivering siRNA and mRNA for simultaneous restoration and silencing of gene/protein expression in vitro and invivo

S. Manturthi, S. El-Sahli, Y. Bo, E. Durocher, M. Kirkby, A. Popatia, K. Mediratta, R. Daniel, S.- H. Lee, U. Iqbal, M. Cote, L. Wang, S. Gadde

This study develops nanoparticles that co-deliver siRNA and mRNA to simultaneously silence and restore gene/protein expression in vitro and in vivo.

bioRxiv · Jun 22, 2024 · PreprintBioengineering

Foam cell induction activates AMPK but uncouples its regulation of autophagy and lysosomal homeostasis

N. D. LeBlond, J. R. C. Nunes, T. K. T. Smith, S. Robichaud, S. Gadde, M. Cote, B. E. Kemp, M. Ouimet, M. D. Fullerton

This study shows that AMPK activation in foam cells disrupts lysosomal homeostasis despite maintaining basal AMPK signaling, suggesting a loss of AMPK's regulatory capacity in atherosclerosis.

bioRxiv · Aug 13, 2020Cell Biology

Characterization of LXR-activating nanoparticle formulations in primary mouse macrophages

T. T. Smith, Z. Kahiel, N. D. LeBlond, P. Ghorbani, E. Farah, M. Cote, S. Gadde, M. D. Fullerton

This study compares three nanoparticle formulations for delivering an LXR activator to mouse macrophages, finding that redox-sensitive formulations enhance ABCA1 protein expression.

bioRxiv · Aug 25, 2019Biochemistry