Author

N. D. LeBlond

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. D. Fullerton· 4 shared P. Ghorbani· 3 shared C. O'Dwyer· 2 shared J. R. Nunes· 2 shared M. Cote· 2 shared S. Gadde· 2 shared T. T. Smith· 2 shared B. E. Kemp· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCell Biology

M. D. Fullerton

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4 papers

Recent·Most cited

Foam cell induction activates AMPK but uncouples its regulation of autophagy and lysosomal homeostasis

N. D. LeBlond, J. R. C. Nunes, T. K. T. Smith, S. Robichaud, S. Gadde, M. Cote, B. E. Kemp, M. Ouimet, M. D. Fullerton

This study shows that AMPK activation in foam cells disrupts lysosomal homeostasis despite maintaining basal AMPK signaling, suggesting a loss of AMPK's regulatory capacity in atherosclerosis.

bioRxiv · Aug 13, 2020Cell Biology

Myeloid deletion and therapeutic activation of AMP-activated protein kinase (AMPK) do not alter atherosclerosis in male or female mice

N. D. LeBlond, P. Ghorbani, C. O'Dwyer, N. Ambursley, J. R. Nunes, T. K. Smith, N. A. Trzaskalski, E. E. Mulvihill, V. Benoit, M. Foretz, M. D. Fullerton

This study shows that deleting AMPK in myeloid cells or activating it therapeutically does not affect atherosclerosis in male or female mice.

bioRxiv · Jul 15, 2020 · PreprintBiochemistry

Characterization of LXR-activating nanoparticle formulations in primary mouse macrophages

T. T. Smith, Z. Kahiel, N. D. LeBlond, P. Ghorbani, E. Farah, M. Cote, S. Gadde, M. D. Fullerton

This study compares three nanoparticle formulations for delivering an LXR activator to mouse macrophages, finding that redox-sensitive formulations enhance ABCA1 protein expression.

bioRxiv · Aug 25, 2019Biochemistry

Fatty acid-induced lipotoxicity inhibits choline metabolism independent of ER stress in mouse primary hepatocytes

C. O'Dwyer, R. Yaworski, N. D. LeBlond, P. Ghorbani, J. R. Nunes, K. D. Margison, T. T. Smith, K. Gobeil Odai, S. Han, M. D. Fullerton

This study shows that fatty acid-induced lipotoxicity reduces choline uptake and PC synthesis in mouse hepatocytes, independent of ER stress.

bioRxiv · Aug 25, 2019 · PreprintCell Biology