S. Alexander

High-throughput, label-free detection of DNA origami in single-cell suspensions using origamiFISH-Flow

The paper introduces origamiFISH-Flow, a high-throughput, label-free method for detecting DNA origami in single-cell suspensions, showing improved sensitivity and enabling cell-type-specific uptake profiling.

Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus

This study shows that vitamin D deficiency in adult mice impairs spatial memory and reduces hippocampal nNOS and NO levels, which can be reversed by vitamin D supplementation.

Nanoscale 3D DNA tracing in single human cells visualizes loop extrusion directly in situ

This study uses nanoscale 3D imaging to show that DNA folds as flexible coils without loop extruding enzymes, but forms reproducible loops with Cohesin and CTCF.

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

First complete genome sequences of Streptococcus pyogenes NCTC 8198T and CCUG 4207T, the type strain of the type species of the genus Streptococcus: 100% match in length and sequence identity between PacBio solo and Illumina plus Oxford Nanopore hybrid assemblies

Freewater EstimatoR using iNtErpolated iniTialization (FERNET): Toward Accurate Estimation of Free Water in Peritumoral Region Using Single-Shell Diffusion MRI Data

FERNET improves free water estimation in peritumoral regions using single-shell diffusion MRI data, enhancing tractography in brain tumor patients.

Correlative live and super-resolution imaging reveals the dynamic structure of replication domains

The paper uses correlative live and super-resolution microscopy to study replication domain structure and dynamics in higher eukaryotes, finding RDs are 150 nm in size with specific spacing and mechanical coupling.