Author

S. J. Ludtke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Research Focus:protein structure prediction· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

G. Fan· 2 shared I. I. Serysheva· 2 shared M. L. Baker· 2 shared M. R. Baker· 2 shared A. B. Serysheva· 1 shared A. Seryshev· 1 shared D. I. Yule· 1 shared E. R. Georgieva· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBiophysics

G. Fan

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Author profile →

4 papers

Recent·Most cited

HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association

S. Majeed, L. Dang, M. M. Islam, O. Ishola, P. P. Borbat, S. J. Ludtke, E. R. Georgieva

The paper shows HIV-1 Vpu forms stable aqueous oligomers via its transmembrane domain self-association, identified through cryoEM, EPR, and size exclusion chromatography.

bioRxiv · May 8, 2023Biophysics

Structural dynamics underlying gating and regulation in IP3R channel

G. Fan, M. R. Baker, L. E. Terry, V. Arige, M. Chen, A. Seryshev, M. L. Baker, S. J. Ludtke, D. I. Yule, I. I. Serysheva

The paper determines 3D structures of IP3R1 in two ligand-bound states using cryo-EM and identifies dynamic properties of key domains involved in ligand binding and channel gating.

bioRxiv · May 27, 2022Biophysics

Improvement of cryo-EM maps by density modification

T. C. Terwilliger, S. J. Ludtke, R. J. Read, P. D. Adams, P. V. Afonine

This paper introduces a density modification method for improving cryo-EM maps by combining half-map information and a model, enhancing map quality and detail visibility.

bioRxiv · Mar 25, 2020Biochemistry

Cryo-EM Reveals Ligand Induced Allostery Underlying InsP3R Channel Gating

G. Fan, M. R. Baker, Z. Wang, A. B. Serysheva, S. J. Ludtke, M. L. Baker, I. I. Serysheva

The paper presents cryo-EM structures of InsP3R1 in activated and apo-states, revealing ligand-induced conformational changes that underlie channel gating.

bioRxiv · Jul 23, 2018Biophysics