Author

M. L. Baker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Organism:chicken / avian· 1

Frequent Co-Authors

G. Fan· 2 shared I. I. Serysheva· 2 shared M. R. Baker· 2 shared S. J. Ludtke· 2 shared A. B. Serysheva· 1 shared A. Johnson· 1 shared A. Kryshtafovych· 1 shared A. Nicolas· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

G. Fan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Faecal virome of the Australian grey-headed flying fox from urban/suburban environments contains novel coronaviruses, retroviruses and sapoviruses

K. V. Brussel, J. E. Mahar, A. S. E. Ortiz-Baez, M. Carrai, D. Spielman, W. S. Boardman, M. L. Baker, J. A. Beatty, J. L. Geoghegan, V. R. Barrs, E. C. Holmes

The paper characterizes the faecal virome of Australian grey-headed flying foxes, identifying novel coronaviruses, retroviruses, and sapoviruses.

bioRxiv · Jul 6, 2022Microbiology

Structural dynamics underlying gating and regulation in IP3R channel

G. Fan, M. R. Baker, L. E. Terry, V. Arige, M. Chen, A. Seryshev, M. L. Baker, S. J. Ludtke, D. I. Yule, I. I. Serysheva

The paper determines 3D structures of IP3R1 in two ligand-bound states using cryo-EM and identifies dynamic properties of key domains involved in ligand binding and channel gating.

bioRxiv · May 27, 2022Biophysics

Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

C. L. Lawson, A. Kryshtafovych, P. D. Adams, P. Afonine, M. L. Baker, B. A. Barad, P. Bond, T. Burnley, R. Cao, J. Cheng, G. Chojnowski, K. Cowtan, K. A. Dill, F. DiMaio, D. Farrell, , Wan

The paper evaluates cryo-EM model quality using benchmark maps, showing high accuracy and reproducibility across 13 teams and recommending multiple metrics for model assessment.

bioRxiv · Jun 12, 2020Biochemistry

Unique Evolution of Antiviral Tetherin in Bats

J. A. Hayward, M. Tachedjian, A. Johnson, A. T. Irving, T. B. Gordon, J. Cui, A. Nicolas, I. Smith, V. Boyd, G. A. Marsh, M. L. Baker, L.-F. Wang, G. Tachedjian

This study characterizes the evolution of tetherin in bats, identifying unique structural variants and splice isoforms with antiviral functions.

bioRxiv · Apr 8, 2020Evolutionary Biology

Cryo-EM Reveals Ligand Induced Allostery Underlying InsP3R Channel Gating

G. Fan, M. R. Baker, Z. Wang, A. B. Serysheva, S. J. Ludtke, M. L. Baker, I. I. Serysheva

The paper presents cryo-EM structures of InsP3R1 in activated and apo-states, revealing ligand-induced conformational changes that underlie channel gating.

bioRxiv · Jul 23, 2018Biophysics