Author

G. Minuesa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

A. Kentsis· 2 shared L. Forbes· 2 shared M. G. Kharas· 2 shared A. Chow· 1 shared A. Krivtsov· 1 shared A. Rizzi· 1 shared A. Schurer· 1 shared B. Knoechel· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

A. Kentsis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

S. Takao, L. Forbes, M. Uni, S. Cheng, J. M. B. Pineda, Y. Tarumoto, P. Cifani, G. Minuesa, C. Chen, M. G. Kharas, R. K. Bradley, C. R. Vakoc, R. P. Koche, A. Kentsis

This study identifies aberrant MYB complex assembly as a driver of oncogenic gene expression in AML and shows that targeting this complex can induce differentiation and apoptosis.

bioRxiv · May 5, 2020Cancer Biology

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

G. Minuesa, S. K. Albanese, A. Chow, A. Schurer, S.-M. Park, C. Z. Rotsides, J. Taggart, A. Rizzi, L. N. Naden, T. Chou, S. Gourkanti, D. Cappel, M. C. Passarelli, L. Fairchild, C. Adura, , M. G. Kharas

This study identifies Ro 08-2750 as a small molecule that targets MSI2 RNA-binding activity, inducing differentiation, apoptosis, and reduced disease burden in AML models.

Nature Communications · Jun 19, 2019Peer-reviewedCancer Biology

Peptidomimetic blockade of MYB in acute myeloid leukemia

K. Ramaswamy, L. Forbes, G. Minuesa, T. Gindin, F. Brown, M. Kharas, A. Krivtsov, S. Armstrong, E. Still, E. de Stanchina, B. Knoechel, R. Koche, A. Kentsis

This study develops a peptidomimetic inhibitor, MYBMIM, that blocks MYB:CBP/P300 complex assembly in AML cells, leading to apoptosis and reduced tumor growth in mice.

bioRxiv · Nov 20, 2017Cancer Biology