MFGE8 inhibits insulin signaling through PTP1B
R. Datta, M. J. Podolsky, C. D. Yang, D. Alba, S. Singh, S. Koliwad, C. O. Lizama, K. Atabai
This study shows MFGE8 inhibits insulin signaling by promoting PTP1B binding to and dephosphorylation of IR{beta}, reducing glucose uptake, and identifies a correlation between serum MFGE8 levels and insulin resistance in humans.
bioRxiv · May 30, 2023 · PreprintPhysiology