S. L. Gupton

The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics

This study shows TRIM9 localizes to dendritic spines and regulates actin dynamics and synaptic responses to netrin-1 during synaptogenesis.

pHusion: A robust and versatile toolset for automated detection and analysis of exocytosis

pHusion is a toolkit for automated exocytosis analysis, showing differences in exocytic frequency and dynamics across cell types.

Multi-monoubiquitination controls VASP-mediated actin dynamics

This study shows that multi-monoubiquitination of VASP at specific lysine residues negatively regulates its actin-binding and bundling activities, affecting cell spreading morphology.

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis

This study identifies novel interactors of TRIM9 and TRIM67 using BioID and validates their roles in neuronal morphogenesis and axonal dynamics.

The ubiquitylome of developing cortical neurons

This study identifies ubiquitylated substrates of TRIM9 and TRIM67 in developing cortical neurons using ubiquitin remnant profiling.

TRIM67 Regulates Exocytic Mode and Neuronal Morphogenesis via SNAP47

The paper identifies four exocytic fusion modes in developing neurons and shows TRIM67 promotes FVF-like exocytosis by limiting SNAP47 incorporation into SNARE complexes.

Dynamic Spatiotemporal Organization of Exocytosis During Cellular Shape Change

The paper investigates the spatiotemporal organization of exocytosis during neuronal shape change and finds distinct patterns in neurons and melanoma cells.

TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching

This study shows TRIM9 ubiquitinates DCC, inhibiting FAK activation, which regulates exocytosis and axon branching in neurons.