S. Le Pennec

Uncoupling splicing from transcription using antisense oligonucleotides reveals a dual role for I exon donor splice sites in antibody class switching

This study uses antisense oligonucleotides to show that I exon donor splice sites are essential for both transcriptional regulation and splicing during antibody class switching.

Distinctive desmoplastic 3D morphology associated with BRAFV600E in papillary thyroid cancers

The paper describes a distinctive 3D morphology in BRAFV600E-mutated papillary thyroid cancers where tumor cells form a sparse mesh within a proliferative stroma, challenging traditional tumor growth models.