A. Marchalot

Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

This paper demonstrates the effectiveness of splice switching oligonucleotides in knocking down c-REL and RELA expression in B cells and plasma cells, with potential therapeutic applications in B-lineage cancers.

Uncoupling splicing from transcription using antisense oligonucleotides reveals a dual role for I exon donor splice sites in antibody class switching

This study uses antisense oligonucleotides to show that I exon donor splice sites are essential for both transcriptional regulation and splicing during antibody class switching.