L. Delpy

A mouse model of cardiac AL amyloidosis unveils mechanisms of tissue accumulation and toxicity of amyloid fibrils

This paper develops a mouse model of cardiac AL amyloidosis that reproduces human disease features, including amyloid deposits and cardiac dysfunction, and identifies a role for partial LC degradation in fibril formation.

Disruption of immunoglobulin heavy and light chain assembly by antisense oligonucleotides impairs protein homeostasis and myeloma cell survival

This study shows that antisense oligonucleotides targeting IgG mRNA reduce IgG secretion in myeloma cells, leading to toxic free-light chain accumulation and cell death.

Transcutaneous penetration of a single-chain variable fragment (scFv) compared to a full-size antibody: potential tool for Atopic Dermatitis (AD) treatment

This study compares the transcutaneous penetration of a single-chain variable fragment (scFv) and a full-size antibody, showing scFv penetrates deeper and more effectively neutralizes hIL-4 in AD models.

Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

This paper demonstrates the effectiveness of splice switching oligonucleotides in knocking down c-REL and RELA expression in B cells and plasma cells, with potential therapeutic applications in B-lineage cancers.

Uncoupling splicing from transcription using antisense oligonucleotides reveals a dual role for I exon donor splice sites in antibody class switching

This study uses antisense oligonucleotides to show that I exon donor splice sites are essential for both transcriptional regulation and splicing during antibody class switching.

Glomerulosclerosis and kidney failure in a mouse model of monoclonal immunoglobulin light-chain deposition disease

This study develops a mouse model of light chain deposition disease, showing that pathogenic light chains cause glomerulosclerosis and kidney failure, and identifies potential therapeutic targets.