Author

S. Lingadahalli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2

Frequent Co-Authors

N. A. Lack· 3 shared A. Cherkasov· 2 shared C. Collins· 2 shared I. P. L. Yu· 2 shared M. E. Gleave· 2 shared T. Morova· 2 shared U. B. Altintas· 2 shared W. Zwart· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

N. A. Lack

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Author profile →

4 papers

Recent·Most cited

HOXB13 alters chromatin accessibility in prostate cancer through interactions with the SWI/SNF complex

S. Lingadahalli, B. E. Fazlioglu, U. B. Altintas, A. Cingoz, E. Tekoglu, I. P. L. Yu, H. Andomat, I. Kulac, T. Morova, K. Xiao, U. M. Dikbas, M. Gleave, L. Fazli, P. Cejas, H. Long, , N. A. Lack

This study shows HOXB13 promotes prostate cancer proliferation by altering chromatin accessibility through interactions with the SWI/SNF complex, particularly in AR-negative castration-resistant prostate cancer.

bioRxiv · Sep 4, 2023 · PreprintCancer Biology

Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression.

F. Zhang, S. Wong, J. Lee, S. Lingadahalli, C. Wells, N. Saxena, C. Sanchez, B. Sun, A. K. Parra-Nunez, N. Chan, J. M. Bui, Y. Wang, P. S. Rennie, N. A. Lack, A. Cherkasov, , N. Lallous

This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.

bioRxiv · Mar 27, 2021Cancer Biology

Functional mapping of androgen receptor enhancer activity

C.-C. F. Huang, S. Lingadahalli, T. Morova, D. Ozturan, E. Hu, I. P. L. Yu, S. Linder, M. Hoogstraat, S. Stelloo, F. Sar, H. van der Poel, U. B. Altintas, M. Saffarzadeh, S. Le Bihan, B. McConeghy, , N. A. Lack

The paper functionally maps AR enhancer activity using STARRseq, finding most AR binding sites are inactive or constitutively active, with inducible enhancers forming regulatory hubs that drive gene transcription.

bioRxiv · Aug 18, 2020Cancer Biology

A novel long noncoding RNA LINC00844 regulates prostate cancer cell migration and invasion through androgen receptor signaling

S. Lingadahalli, S. Jadhao, Y. Y. Sung, M. Chen, L. Hu, X. Chen, E. Cheung

This study identifies LINC00844 as an androgen-regulated lncRNA that suppresses prostate cancer migration and invasion by modulating AR chromatin binding and NDRG1 expression.

bioRxiv · Jan 7, 2018Cancer Biology