A. Cherkasov

5'-S-(3-aminophenyl)-5'-thioadenosine, a novel chemoprotective agent for reducing toxic side effects of fluorouracil in treatment of MTAP-deficient cancers

This paper identifies m-APTA, an MTA analogue that reduces NBA toxicity without hypothermia, improving safety for MTAP-deficient cancer treatment.

HOXB13 alters chromatin accessibility in prostate cancer through interactions with the SWI/SNF complex

This study shows HOXB13 promotes prostate cancer proliferation by altering chromatin accessibility through interactions with the SWI/SNF complex, particularly in AR-negative castration-resistant prostate cancer.

Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression.

This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.

Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes

The paper shows IL10 induces a SHIP1/STAT3 complex in macrophages, and SHIP1 activators mimic IL10's anti-inflammatory effects in colitis.

Deep Learning Modelling of Androgen Receptor Responses to Prostate Cancer Therapies

This study develops a deep neural network to predict Androgen Receptor mutant responses to prostate cancer therapies, showing improved accuracy over other machine learning methods.