N. Chan

Cntnap2 deletion in mice causes developmentally transient alterations in auditory processing and persistent startle hyperreactivity

This study shows that Cntnap2 deletion in mice causes transient auditory brainstem changes and persistent startle hyperreactivity in males, similar to rats but with sex-specific effects.

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

Integration of homeostatic and adaptive oxidative responses by a putative co-chaperone, Wos2, drives fungal virulence in cryptococcosis

This study identifies Wos2 as a co-chaperone that integrates oxidative stress responses in Cryptococcus neoformans, contributing to virulence and offering a potential drug target for antifungal therapy.

Hourglass, a tool to mine bioimaging data, uncovers sex-disparities in the IL-6-associated T cell response in pancreatic tumors

Hourglass processes bioimaging data to reveal sex-specific IL-6 effects on T cell responses in pancreatic tumors.

Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression.

This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.

REGEN-COV protects against viral escape in preclinical and human studies

This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.

Commensal Microbiota Regulates Skin Barrier Function And Repair Via Signaling Through The Aryl Hydrocarbon Receptor