Author

S. Loghavi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:bulk RNA-seq· 2 Assay:clinical cohort / trial· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G. Garcia-Manero· 3 shared G. Montalban-Bravo· 3 shared R. Kanagal-Shamanna· 3 shared D. Hammond· 2 shared F. Ma· 2 shared I. Ganan-Gomez· 2 shared K. Chien· 2 shared K. Sasaki· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

G. Garcia-Manero

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

W. C. Fiskus, J. Piel, M. Collins, M. Hentemann, B. Cuglievan, C. P. Mill, C. E. Birdwell, K. Das, J. A. Davis, H. Hou, A. C. Jain, A. Malovannaya, T. M. Kadia, N. Daver, K. Sasaki, , K. N. Bhalla

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

bioRxiv · Sep 28, 2023Cancer Biology

IL-1B-mediated inflammatory signaling drives ineffective erythropoiesis in early-stage myelodysplastic syndromes

V. Adema, I. Ganan-Gomez, F. Ma, J. J. Rodriguez-Sevilla, K. Chien, H. Yang, N. Thongon, R. Kanagal-Shamanna, S. Loghavi, G. Montalban-Bravo, D. Hammond, Y. Gu, R. Tan, L. Tan, P. Lorenzi, , S. Colla

This study shows that IL-1B-mediated inflammation drives ineffective erythropoiesis in early-stage MDS and that canakinumab can reduce transfusion dependence in patients with DNMT3A and TET2 mutations.

bioRxiv · Sep 28, 2023 · PreprintCancer Biology

Hematopoietic Stem Cells Undergo Differentiation State Reprogramming to Overcome Venetoclax Sensitivity in Patients with Myelodysplastic Syndromes

J. J. Rodriguez Sevilla, I. Ganan-Gomez, F. Ma, K. Chien, G. Montalban-Bravo, R. Kanagal-Shamanna, S. Loghavi, V. Adema, A. Bazinet, G. Garcia-Manero, S. Colla

This study shows MDS hematopoietic stem cells reprogram their differentiation state to bypass venetoclax sensitivity through genetic mutations and transcriptional changes.

bioRxiv · Sep 25, 2023 · PreprintCancer Biology

Clinicopathologic Correlates and Natural History of Atypical Chronic Myeloid Leukemia

G. Montalban-Bravo, R. Kanagal-Shamanna, K. Sasaki, L. Masarova, K. Naqvi, E. Jabbour, C. DiNardo, K. Takahashi, M. Konopleva, N. Pemmaraju, T. M. Kadia, F. Ravandi, N. G. Daver, G. M. Borthakur, Z. E. Estrov, , G. Garcia-Manero

This study examines clinicopathologic features and treatment outcomes in 65 patients with atypical chronic myeloid leukemia, identifying key mutations and predictors of survival.

bioRxiv · Sep 10, 2020Cancer Biology