R. Tan

Mutation of phosphatidate phosphohydrolase genes confers broad-spectrum disease resistance in plants

The paper shows that mutating phosphatidate phosphohydrolase (PAH) genes in rice and Arabidopsis increases phosphatidic acid (PA) levels and broad-spectrum disease resistance.

Nanofibrous Wound Dressing with a Smart Drug Delivery System: Poly(N-Isopropylacrylamide)-Conjugated Polycaprolactone Nanofibers Loaded with Curcumin

This paper develops a smart wound dressing using PCL nanofibers conjugated with PNIPAAm and loaded with curcumin, showing controlled drug release and enhanced wound healing.

Formylation facilitates the reduction of oxidized initiator methionines

This study shows that formylation of initiator methionines enhances their enzymatic reduction and mitigates oxidation-related misprocessing.

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.

IL-1B-mediated inflammatory signaling drives ineffective erythropoiesis in early-stage myelodysplastic syndromes

This study shows that IL-1B-mediated inflammation drives ineffective erythropoiesis in early-stage MDS and that canakinumab can reduce transfusion dependence in patients with DNMT3A and TET2 mutations.

Methionine Alkylation as an Approach to Quantify Methionine Oxidation Using Mass Spectrometry

This paper introduces MObBa, a mass spectrometry method to quantify methionine oxidation by alkylating unoxidized methionines, enabling accurate measurement of oxidation levels in peptides and proteomes.

A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

This paper introduces a high-throughput single-molecule tracking platform to study protein dynamics and drug interactions, identifying novel mechanisms and therapeutics.

Folding stabilities of ribosome-bound nascent polypeptides probed by mass spectrometry

This study uses mass spectrometry to measure how ribosome binding affects the folding stability of nascent polypeptides, finding that ribosome-induced stability changes depend on localized charge distributions.

Microtubule Lattice Spacing Governs Cohesive Envelope Formation of Tau Family Proteins

This study shows that tau family proteins form cohesive envelopes around microtubules, regulated by lattice spacing, which differentially affects motor protein movement and microtubule function.

Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation

This study characterizes the structure and function of TMPRSS2, a protease involved in SARS-CoV-2 activation, and identifies features for developing selective inhibitors.

Differential activation of parathyroid and renal Ca2+-sensing receptors underlies the renal phenotype in autosomal dominant hypocalcemia 1

This study shows that parathyroid and renal Ca2+-sensing receptors have different activation thresholds in ADH1, explaining why some patients have low PTH without hypercalciuria.

Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth

The paper investigates the role of Cln3 and Whi5 in linking cell cycle entry to growth in budding yeast, finding that Cln3 concentration increases with growth to drive cell cycle entry.

Virome-wide serological profiling reveals association of herpesviruses with obesity

This study uses ViScan to find HSV-1 and Rhinovirus A associations with obesity in Qatari adults, but not children.

Socio-Ecological Network Structures from Process Graphs

This paper introduces a process graph (P-graph) framework to model and analyze ecological networks, enabling the study of ecosystem compartment interactions and resilience.

A Metagenomics - Based Diagnostic Approach for Central Nervous System Infections in Hospital Acute Care Setting

This study develops a metagenomics-based diagnostic approach for CNS infections using mNGS, showing 95% accuracy in detecting pathogens in CSF samples compared to conventional methods.

A novel real-time PCR assay panel for detection of common respiratory pathogens in a convenient, strip-tube array format

The paper develops and validates a real-time PCR assay (Respanel) for detecting respiratory pathogens, showing higher sensitivity than Resplex and comparable performance to FTDRP21.

Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functions

The paper shows microtubules regulate tau condensation, which spatially controls microtubule severing enzymes and motor movement.

Planktonic interference and biofilm alliance between aggregation substance and endocarditis and biofilm associated pili in Enterococcus faecalis

This study examines the co-expression of aggregation substance (AS) and endocarditis and biofilm-associated pili (Ebp) in Enterococcus faecalis, showing their antagonistic and synergistic effects in planktonic growth and biofilm formation.

Cooperative Accumulation Of Dynein-Dynactin At Microtubule Minus-Ends Drives Microtubule Network Reorganization

This study identifies how dynein-dynactin complexes accumulate at microtubule minus-ends to drive MT sliding, clustering, aster formation, and network contraction during mitosis.