K. Sasaki

Using variable data independent acquisition for capillary electrophoresis-based untargeted metabolomics

This study evaluates DIA techniques for CE-MS/MS metabolomics, showing vDIA with MS-DIAL improves annotation rates and accuracy, and identifies new metabolites in LPS-treated macrophages.

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

This study shows that an ENL mutation disrupts kidney development by altering gene regulation, leading to developmental defects and early death in mice, and suggests potential therapeutic strategies.

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

Number of kinesins engaged in axonal cargo transport: A novel biomarker for neurological disorders

The paper reviews a model to quantify kinesin molecules engaged in axonal cargo transport and suggests their number could serve as biomarkers for neurodegenerative diseases.

Modeling the motion of disease-associated KIF1A heterodimers

This paper develops mathematical models to explain the motility of KIF1A heterodimers, showing that a coordinated head model better predicts experimental results than an independent head model.

Cell wall pectic β-1,4-galactan contributes to increased plant freezing tolerance induced by cold acclimation

This study shows that cold acclimation increases β-1,4-galactan in plant cell walls, improving freezing tolerance by altering cell wall mechanical properties.

The cholesterol pathway of the Golgi stress response induces cell death and transcription of Golgi-related genes through metabolic dysregulation of phosphatidylinositol-4-phosphate

Expression of transcription factors KLF2 and KLF4 is induced by the mammalian Golgi stress response

The paper identifies KLF2 and KLF4 as transcription factors induced by PG-type Golgi stress and involved in regulating proteoglycan pathways.

Uncovering plant microbiomes using long-read metagenomic sequencing

The paper uses long-read metagenomic sequencing to analyze the rice leaf microbiome, identifying novel bacterial species and genetic elements.

Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation

This paper develops a method to estimate crossbridge-state in cardiomyocytes using SHG polarization, showing its applicability in assessing myosin force generation and drug effects.

Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell therapy

This study develops STEAP1 CAR T cell therapy for advanced prostate cancer, showing potent antitumor activity and safety in preclinical models, but also identifies antigen loss as a resistance mechanism.

Genes responsible for avoiding attack of a beetle, relating to the duration of death feigning

The paper compares DNA variation between two Tribolium castaneum strains with different death-feigning durations to identify genes associated with this behavior.

Arf GTPase-Activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor

This study identifies SMAP1 and AGFG2 as ArfGAPs regulating Weibel-Palade body size and von Willebrand factor exocytosis, respectively.

An early-morning flowering trait in rice helps retain grain yield under heat stress field conditions at flowering stage

This study shows that the early-morning flowering trait in rice improves grain yield under heat stress by reducing spikelet sterility.

Clinicopathologic Correlates and Natural History of Atypical Chronic Myeloid Leukemia

This study examines clinicopathologic features and treatment outcomes in 65 patients with atypical chronic myeloid leukemia, identifying key mutations and predictors of survival.

Only SF3B1 Mutation involving K700E (And Not Other Codons), Independently Predicts Overall Survival in Myelodysplastic Syndromes

This study shows that SF3B1 mutations specifically at codon K700E, but not other codons, are independently linked to better overall survival in myelodysplastic syndromes.

A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of Diffuse Large B-cell Lymphoma

The paper identifies a germinal center-associated microenvironmental signature in DLBCL that correlates with prognosis and molecular features, showing its impact on clinical outcomes.

Topological data analysis to uncover the shape of immune responses during co-infection

The paper uses topological data analysis to study immune response dynamics during influenza-pneumococcal co-infection in mice, revealing three phases and two transition points in the immune response.

The two-step chemosensory system underlying the oligophagy of silkworm larvae

This study identifies a two-step chemosensory system in silkworm larvae that integrates plant chemical cues to determine host acceptance.

MGSE regulates crosstalk from the mucin pathway to the TFE3 pathway of the Golgi stress response

The paper identifies a novel mucin pathway that enhances glycosylation enzyme expression during mucin-type Golgi stress and shows it activates the TFE3 pathway through a specific enhancer element.