Author

S. M. Allan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 4 Cell Biology· 1

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. W. McColl· 2 shared C. J. Smith· 2 shared D. Brough· 2 shared J. P. Green· 2 shared L. McCulloch· 2 shared A. Granata· 1 shared A. J. Harris· 1 shared A. Malbon· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

B. W. McColl

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5 papers

Recent·Most cited

The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome.

T. A. Gleeson, C. Kaiser, C. B. Lawrence, D. Brough, S. M. Allan, J. P. Green

This study shows the NLRP3 inflammasome is crucial for IL-18 production in a murine model of MAS but not for other disease features.

bioRxiv · Feb 27, 2024Immunology

A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases in extracellular matrix abnormalities

M. Al-Thani, M. Goodwin-Trotman, S. Bell, K. Patel, L. K. Fleming, C. Vilain, M. Abramowicz, S. M. Allan, T. Wang, Z. Cader, K. Horsburgh, T. Van Agtmael, S. Sinha, H. S. Markus, A. Granata

This paper develops a human iPSC model of COL4A1/A2 small vessel disease, showing that MMP inhibition rescues ECM abnormalities and mural cell defects.

bioRxiv · Feb 23, 2023 · PreprintCell Biology

Treatment with IgM-enriched intravenous immunoglobulins (IgM-IVIg) enhances clearance of stroke-associated bacterial lung infection

L. McCulloch, A. J. Harris, A. Malbon, M. J. D. Daniels, M. Younas, J. R. Grainger, S. M. Allan, C. J. Smith, B. W. McColl

This study shows that IgM-enriched intravenous immunoglobulin (IgM-IVIg) improves bacterial clearance and reduces lung inflammation after stroke.

bioRxiv · Dec 16, 2021Immunology

Itaconate and fumarate derivatives exert a dual inhibitory effect on canonical NLRP3 activation in macrophages and microglia

C. Hoyle, J. P. Green, S. M. Allan, D. Brough, E. Lemarchand

This study shows itaconate and fumarate derivatives inhibit both priming and activation of NLRP3 inflammasome in macrophages and microglia, suggesting their therapeutic potential for NLRP3-driven diseases.

bioRxiv · Feb 1, 2021Immunology

Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence

L. McCulloch, S. M. Allan, C. J. Smith, B. W. McColl

This study examines whether IL-1Ra treatment in acute ischaemic stroke affects systemic anti-microbial defenses, finding no significant differences in immunoglobulin and complement levels between treated and placebo groups.

bioRxiv · Mar 26, 2019Immunology