S. Mairpady Shambat

This study shows that S. aureus alpha-toxin induces CX3CL1 release via ADAM10 in lung epithelium, impairing monocyte bactericidal function through CX3CL1-dependent mechanisms.

This study compares GAS strains from meningitis and otitis cases, finding no distinct invasive traits associated with meningitis.

This study shows that severe hypercytokinemia in COVID-19 patients impairs neutrophil and monocyte function against bacterial challenges, leading to reduced microbicidal capacity and altered receptor signaling.

The paper compares phenotypic and genotypic profiles of S. aureus colonizing and invasive isolates, finding limited genetic evolution and similar traits, with barrier disruption as key to disease progression.

This study quantifies phenotypic heterogeneity in Staphylococcus aureus from patient samples to assess persisters, finding that rifampicin treatment correlates with increased growth delays.

This study evaluates the REPTIS method for detecting antibiotic tolerance in S. aureus isolates from patients, finding regrowth patterns linked to antibiotic targets and patient characteristics.

The paper shows that in critically ill COVID-19 patients, dysregulated Fas signaling leads to increased RIPK1-driven necroptosis in neutrophils, contributing to disease severity.