Author

M. Huemer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 2

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:human· 6 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. S. Zinkernagel· 8 shared S. Mairpady Shambat· 6 shared C. Vulin· 5 shared S. D. Brugger· 5 shared A. Gomez-Mejia· 4 shared R. A. Schuepbach· 4 shared T. A. Schweizer· 4 shared C.-C. Chang· 3 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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8 shared papersMicrobiology

A. S. Zinkernagel

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Alpha-toxin elicited CX3CL1-release via ADAM10 in Staphylococcus aureus pneumoniaimpairs bactericidal function of human monocytes

S. Mairpady Shambat, P. Chen, R. M. Barilla, M. Huemer, J. Snaell, A. Welin, T. S. Cohen, V. Takahashi, S. B. Berry, A. Gomez-Mejia, T. A. Schweizer, D. M. Cunoosamy, S. Cajander, M. Lourdaa, V. Ozenci, , M. Svensson

This study shows that S. aureus alpha-toxin induces CX3CL1 release via ADAM10 in lung epithelium, impairing monocyte bactericidal function through CX3CL1-dependent mechanisms.

bioRxiv · Sep 17, 2023 · PreprintMicrobiology

Group A Streptococcus antibiotic tolerance in necrotizing fasciitis

N. Keller, M. Boumasmoud, F. Andreoni, A. Tarnutzer, M. von Matt, T. C. Scheier, A. Gomez-Mejia, M. Huemer, E. Marques-Maggio, R. A. Schuepbach, S. Mairpady-Shambat, S. D. Brugger, A. S. Zinkernagel

This study shows that Group A Streptococcus (GAS) persisters are present in tissue from necrotizing fasciitis patients and contribute to antibiotic treatment failure.

bioRxiv · Aug 19, 2022 · PreprintMicrobiology

Neutrophil and monocyte dysfunctional effector response towards bacterial challenge in critically-ill COVID-19 patients

S. Mairpady Shambat, A. Gomez-Mejia, T. A. Schweizer, M. Huemer, C.-C. Chang, C. Acevedo, J. Bergada Pijuan, C. Vulin, N. Miroshnikova, D. A. Hofmanner, P. D. Wendel Garcia, M. P. Hilty, P. K. Buehler, R. A. Schuepbach, S. D. Brugger, A. S. Zinkernagel

This study shows that severe hypercytokinemia in COVID-19 patients impairs neutrophil and monocyte function against bacterial challenges, leading to reduced microbicidal capacity and altered receptor signaling.

PLOS Pathogens · Jan 10, 2022Peer-reviewedImmunology

Quantification of within patient Staphylococcus aureus phenotypic heterogeneity as a proxy for presence of persisters across clinical presentations

J. Baer, M. Boumasmoud, S. Mairpady Shambat, C. Vulin, M. Huemer, T. A. Schweizer, A. Gómez Mejia, N. Eberhard, Y. Achermann, P. O. Zingg, C. A. Mestres, S. D. Brugger, R. A. Schüpbach, R. D. Kouyos, B. Hasse, A. S. Zinkernagel

This study quantifies phenotypic heterogeneity in Staphylococcus aureus from patient samples to assess persisters, finding that rifampicin treatment correlates with increased growth delays.

bioRxiv · Jul 27, 2021Microbiology

Assessing antibiotic tolerance of Staphylococcus aureus derived directly from patients by the Replica Plating Tolerance Isolation System- REPTIS

S. Herren, M. Huemer, C. T. Acevedo, F. Andreoni, A. Gomez Mejia, S. Mairpady Shambat, B. K. Hasse, R. Zbinden, S. D. Brugger, A. S. Zinkernagel

This study evaluates the REPTIS method for detecting antibiotic tolerance in S. aureus isolates from patients, finding regrowth patterns linked to antibiotic targets and patient characteristics.

bioRxiv · May 12, 2021Microbiology

Ser/Thr phospho-regulation by PknB and Stp mediates bacterial quiescence and antibiotic persistence in Staphylococcus aureus

M. Huemer, S. Mairpady Shambat, S. Pereira, L. Van Gestel, J. Bergada-Pijuan, A. Gomez Mejia, C.-C. Chang, C. Vulin, J. Baer, J. Dworkin, A. S. Zinkernagel

bioRxiv · May 6, 2021Microbiology

Blunted Fas signaling favors RIPK1-driven neutrophil necroptosis in critically ill COVID-19 patients

T. A. Schweizer, S. Mairpady Shambat, C. Vulin, S. Hoeller, C. Acevedo, M. Huemer, A. Gomez-Mejia, C.-C. Chang, J. Baum, S. Hertegonne, E. Hitz, D. A. Hofmaenner, P. K. Buehler, H. Moch, R. A. Schuepbach, , A. S. Zinkernagel

The paper shows that in critically ill COVID-19 patients, dysregulated Fas signaling leads to increased RIPK1-driven necroptosis in neutrophils, contributing to disease severity.

bioRxiv · Mar 19, 2021 · PreprintImmunology

Prolonged lag time results in small colony variants and reflects a sub-population of persisters in vivo

C. Vulin, N. Leimer, M. Huemer, M. Ackermann, A. S. Zinkernagel

The paper shows that small colony variants in Staphylococcus aureus result from prolonged lag times, not mutations, and are linked to antibiotic tolerance and persisters in vivo.

bioRxiv · Mar 12, 2018Microbiology

Peatland Acidobacteria with a dissimilatory sulfur metabolism

B. Hausmann, C. Pelikan, C. W. Herbold, S. Koestlbacher, M. Albertsen, S. A. Eichorst, T. Glavina del Rio, M. Huemer, P. H. Nielsen, T. Rattei, U. Stingl, S. G. Tringe, D. Trojan, C. Wentrup, D. Woebken, , A. Loy

The paper identifies novel Acidobacteria in peatlands with sulfur metabolism capabilities, including both sulfate respiration and sulfur oxidation, and highlights their ecological roles in organic matter decomposition.

bioRxiv · Oct 2, 2017Microbiology