A. S. Zinkernagel

This study shows that S. aureus alpha-toxin induces CX3CL1 release via ADAM10 in lung epithelium, impairing monocyte bactericidal function through CX3CL1-dependent mechanisms.

This study shows that high c-di-AMP levels in Staphylococcus aureus increase cell wall thickness and antibiotic resistance, while reducing cell size and antioxidant production.

This study shows that Group A Streptococcus (GAS) persisters are present in tissue from necrotizing fasciitis patients and contribute to antibiotic treatment failure.

This paper evaluates SESI-HRMS for rapid detection of S. aureus and S. pneumoniae by analyzing VOCs, showing faster and more sensitive identification than conventional methods.

This study investigates S. aureus spondylodiscitis by combining clinical data and an ex vivo porcine model, showing IVD cell death and neutrophil recruitment.

This study shows that severe hypercytokinemia in COVID-19 patients impairs neutrophil and monocyte function against bacterial challenges, leading to reduced microbicidal capacity and altered receptor signaling.

The paper compares phenotypic and genotypic profiles of S. aureus colonizing and invasive isolates, finding limited genetic evolution and similar traits, with barrier disruption as key to disease progression.

This study quantifies phenotypic heterogeneity in Staphylococcus aureus from patient samples to assess persisters, finding that rifampicin treatment correlates with increased growth delays.

This study evaluates the REPTIS method for detecting antibiotic tolerance in S. aureus isolates from patients, finding regrowth patterns linked to antibiotic targets and patient characteristics.

This study identifies a linear plasmid in vancomycin-resistant Enterococcus faecium that confers a nutrient utilization advantage, contributing to its spread in a hospital setting.

The paper shows that in critically ill COVID-19 patients, dysregulated Fas signaling leads to increased RIPK1-driven necroptosis in neutrophils, contributing to disease severity.

This study compares SARS-CoV-2-specific antibody responses in mild and severe COVID-19 patients and healthcare workers, finding higher systemic IgA and IgG in severe cases and mucosal IgA in asymptomatic exposed individuals.

This paper introduces baQFA, a low-cost high-throughput method to quantify bacterial reproductive fitness with and without antimicrobial resistance using time-lapse imaging and Gompertz modeling.

The paper shows that small colony variants in Staphylococcus aureus result from prolonged lag times, not mutations, and are linked to antibiotic tolerance and persisters in vivo.