S. D. Brugger

Group A Streptococcus strains causing meningitis without distinct invasive phenotype

This study compares GAS strains from meningitis and otitis cases, finding no distinct invasive traits associated with meningitis.

Computational and in vitro evaluation of probiotic treatments for nasal Staphylococcus aureus decolonization

This paper evaluates probiotic and antibiotic treatments for nasal Staphylococcus aureus decolonization using computational modeling and in vitro experiments, finding probiotics outperform antibiotics in decolonization and recolonization robustness.

Group A Streptococcus antibiotic tolerance in necrotizing fasciitis

This study shows that Group A Streptococcus (GAS) persisters are present in tissue from necrotizing fasciitis patients and contribute to antibiotic treatment failure.

Rapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites

This paper evaluates SESI-HRMS for rapid detection of S. aureus and S. pneumoniae by analyzing VOCs, showing faster and more sensitive identification than conventional methods.

Intervertebral disc cell chondroptosis elicits neutrophil response in Staphylococcus aureus spondylodiscitis

This study investigates S. aureus spondylodiscitis by combining clinical data and an ex vivo porcine model, showing IVD cell death and neutrophil recruitment.

Neutrophil and monocyte dysfunctional effector response towards bacterial challenge in critically-ill COVID-19 patients

This study shows that severe hypercytokinemia in COVID-19 patients impairs neutrophil and monocyte function against bacterial challenges, leading to reduced microbicidal capacity and altered receptor signaling.

Limited adaptive evolution of Staphylococcus aureus during transition from colonization to invasive infection

The paper compares phenotypic and genotypic profiles of S. aureus colonizing and invasive isolates, finding limited genetic evolution and similar traits, with barrier disruption as key to disease progression.

Quantification of within patient Staphylococcus aureus phenotypic heterogeneity as a proxy for presence of persisters across clinical presentations

This study quantifies phenotypic heterogeneity in Staphylococcus aureus from patient samples to assess persisters, finding that rifampicin treatment correlates with increased growth delays.

Assessing antibiotic tolerance of Staphylococcus aureus derived directly from patients by the Replica Plating Tolerance Isolation System- REPTIS

This study evaluates the REPTIS method for detecting antibiotic tolerance in S. aureus isolates from patients, finding regrowth patterns linked to antibiotic targets and patient characteristics.

Genomic Stability and Genetic Defense Systems in Dolosigranulum pigrum a Candidate Beneficial Bacterium from the Human Microbiome

This study analyzes the genomic stability and defense mechanisms of Dolosigranulum pigrum, a beneficial human nasal bacterium, using 28 genomes to reveal its chromosomal structure, MGEs, and defense systems.

Blunted Fas signaling favors RIPK1-driven neutrophil necroptosis in critically ill COVID-19 patients

The paper shows that in critically ill COVID-19 patients, dysregulated Fas signaling leads to increased RIPK1-driven necroptosis in neutrophils, contributing to disease severity.

Quantifying variation in bacterial reproductive fitness with and without antimicrobial resistance: a high-throughput method

This paper introduces baQFA, a low-cost high-throughput method to quantify bacterial reproductive fitness with and without antimicrobial resistance using time-lapse imaging and Gompertz modeling.

Dolosigranulum pigrum cooperation and competition in human nasal microbiota

The paper investigates D. pigrum's role in nasal microbiota by analyzing its interactions with other bacteria and genomic features, finding that it inhibits pathogens and relies on host and co-colonizing bacteria for nutrients.