Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest
S. Cho, M. Vashisth, A. Abbas, S. Majkut, K. Vogel, Y. Xia, I. L. Ivanovska, J. Irianto, M. Tewari, K. Zhu, E. D. Tichy, F. Mourkioti, H.-Y. Tang, R. Greenberg, B. L. Prosser, D. E. Discher
The paper shows that lamin-A stabilizes the genome by protecting against nuclear rupture, DNA damage, and cell cycle arrest under mechanical stress.
bioRxiv · Mar 20, 2019Cell Biology