Author

M. Vashisth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

D. E. Discher· 3 shared J. Irianto· 3 shared S. Cho· 3 shared L. J. Dooling· 2 shared Y. Xia· 2 shared A. Abbas· 1 shared A. Liu· 1 shared B. C. Bera· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBioengineering

D. E. Discher

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response

J. C. Andrechak, L. J. Dooling, B. H. Hayes, S. Kadu, W. Zhang, R. Pan, M. Vashisth, J. Irianto, C. M. Alvey, D. E. Discher

This study shows engineered macrophages using cooperative phagocytosis eliminate solid tumours and induce anti-tumour IgG, improving immunotherapy outcomes.

bioRxiv · Jan 1, 2022Bioengineering

Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

C. R. Pfeifer, M. P. Tobin, S. Cho, M. Vashisth, L. J. Dooling, L. L. Vasquez, E. G. Ricci-De Lucca, K. T. Simon, D. E. Discher

The paper shows that high nuclear curvature causes lamin-B dilution and rupture, with lamin-A also contributing under high strain rates, suggesting a viscoplastic response to mechanical stress.

bioRxiv · Oct 13, 2021Biophysics

Reduced Lytic Activity of Bacteriophages in Presence of Antibiotics Targeting Bacterial Protein Synthesis

M. Vashisth, S. Yashveer, N. Virmani, B. C. Bera, R. K. Vaid, T. Anand

This study investigates how antibiotics targeting bacterial protein synthesis affect bacteriophage lytic activity, finding antagonistic effects in most cases.

bioRxiv · Jun 30, 2021 · PreprintMicrobiology

Scaling concepts in 'omics: nuclear lamin-B scales with tumor growth and predicts poor prognosis, whereas fibrosis can be pro-survival

M. Vashisth, D. Discher, S. Cho, J. Irianto, Y. Xia, M. Wang, B. Hayes, F. Jafarpour, A. Liu, R. G. Wells

The paper identifies scaling relationships between genes in cancer data, finding LMNB1 correlates with poor prognosis while fibrosis markers predict better survival.

bioRxiv · Feb 25, 2021 · PreprintCancer Biology

Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

S. Cho, M. Vashisth, A. Abbas, S. Majkut, K. Vogel, Y. Xia, I. L. Ivanovska, J. Irianto, M. Tewari, K. Zhu, E. D. Tichy, F. Mourkioti, H.-Y. Tang, R. Greenberg, B. L. Prosser, D. E. Discher

The paper shows that lamin-A stabilizes the genome by protecting against nuclear rupture, DNA damage, and cell cycle arrest under mechanical stress.

bioRxiv · Mar 20, 2019Cell Biology