K. Zhu

Cost-effective genomic prediction for fertility traits: A comparison of machine learning and conventional models using low-coverage sequencing in Holstein heifers

This study compares machine learning and conventional models for genomic prediction of fertility traits in Holstein heifers using low-coverage sequencing data, finding that KRR_GRM improves accuracy over traditional methods when using only genomic data.

Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids

This study identifies natural antibodies that enable Kupffer cells to capture and kill encapsulated bacteria in the liver, offering a potential therapeutic approach for septic bacterial diseases.

Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L

This study shows that nucleic acids can be ubiquitylated by DTX3L, an E3 ligase, and this modification is reversible by DUBs like USP2 and SARS-CoV-2 PLpro.

Functional Diversification of Gene Duplicates under the Constraint of Protein Structure

This study examines gene duplication and divergence in GH50 agarases from Agarivorans ablus, showing structural and functional divergence while maintaining conserved backbone structures.

CoRAL accurately resolves extrachromosomal DNA genomestructures with long-read sequencing

CoRAL improves ecDNA structure reconstruction using long-read sequencing, outperforming short-read methods in simulations and cell-line datasets.

Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

The paper introduces OM2BFB, an algorithm detecting BFB amplifications using OGMs, showing high precision and recall, and finds BFB events are common in certain cancers but not linked to intratumoral heterogeneity or rapid genome change.

Utility of T1 mapping and T2 mapping for non-invasive assessment of liver fibrosis: preclinical results

This study evaluates T1 and T2 mapping for assessing liver fibrosis in mice, finding they correlate with fibrosis stages and collagen/protein markers.

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

Programmable delivery of fluoxetine via wearable bioelectronics for wound healing in vivo

This paper introduces a wearable bioelectronic bandage that delivers fluoxetine on-demand to wounds, reducing inflammation and accelerating healing in mice.

Electrostatic modulation of signaling at cell membrane: Waveform- and time-dependent electric control of ERK dynamics

This study shows that alternating current electric fields can modulate ERK signaling in epithelial cells through waveform- and timing-dependent electrostatic interactions.

PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities

This study identifies PARP14 as a dual-function enzyme with ADP-ribosyl transferase and hydrolase activities, revealing its role in antiviral responses and substrate specificity.

A network of CD163+ macrophages monitors enhanced permeability at the blood-dorsal root ganglion barrier

The paper identifies CD163+ macrophages as key regulators of blood-DRG barrier permeability through caveolar transcytosis and reveals their distinct role in vascular monitoring.

Simulating Rumen Conditions using an Anaerobic Dynamic Membrane Bioreactor to Enhance Hydrolysis of Lignocellulosic Biomass

This study uses an anaerobic dynamic membrane bioreactor to mimic rumen conditions, achieving high hydrolysis and VFA production from food waste.

A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology

This paper shows that macrophage motility patterns and morphology can predict their subtypes, with combined features improving prediction accuracy to 75%.

Propagation dynamics of electrotactic motility in large epithelial cell sheets

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

Structural Characterisation of Nanoparticle-Supported Lipid Bilayers by Grazing Incidence X-ray and Neutron Scattering

This study uses grazing incidence X-ray and neutron scattering to analyze the structure of curved and fluid lipid bilayers formed on nanoparticle arrays, revealing curvature effects on lipid packing.

Truncated suPAR simultaneously causes kidney disease and autoimmune diabetes mellitus

The paper identifies a truncated suPAR fragment, D2D3, that causes kidney disease and autoimmune diabetes by impairing pancreatic beta-cell function and kidney health.

Dynamic Expedition of Leading Mutations in SARS-CoV-2 Spike Glycoproteins

The paper introduces a time-resolved statistical method to analyze the evolutionary dynamics of SARS-CoV-2 spike mutations and quantifies mutation strength using the L-index.

Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation

The paper identifies TOP1 inhibitors as therapeutic agents for neuroinflammation and develops a DNA origami nanosystem for targeted delivery to myeloid cells.

Evaluation of podocyte Rac-1 induced kidney disease by modulation of TRPC5

This study evaluates the role of TRPC5 in podocyte Rac-1 induced kidney disease using transgenic mice and electrophysiological experiments, finding TRPC5 inhibition does not alleviate proteinuria.

Crystal structure of Sulfolobus solfataricus topoisomerase III reveals a novel carboxyl-terminal zinc finger domain essential for decatenation activity

Quantifying the impact of electric fields on single-cell motility

The paper develops and calibrates a stochastic model to predict how electric fields affect single-cell motility, showing that EFs bias motility through one of several hypothetical mechanisms.

A Novel Droplet Digital PCR Human mtDNA Assay for Global Fecal Source Tracking

This paper develops a ddPCR assay for human mtDNA to track fecal sources, finding it more sensitive than a common bacterial marker in human feces from three regions.

PI3K inhibition reverses migratory direction of single cells but not cell groups in electric field

The paper shows that PI3K inhibition reverses single cell migration direction in electric fields but not in large cell groups, with different behavior observed in group interiors and edges.

Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts

The paper identifies a cellular transition from adipose-derived stromal cells to COL11A1-expressing cancer-associated fibroblasts across multiple cancers using single-cell analysis.

Montane species track rising temperatures better in the tropics than in the temperate zone

The paper finds that tropical montane species track temperature increases more effectively than temperate species in two datasets, suggesting a latitudinal gradient in temperature tracking.

scRNA-seq analysis of colon and esophageal tumors uncovers abundant microbial reads in myeloid cells undergoing proinflammatory transcriptional alterations

The paper develops a computational pipeline to identify microbial reads in scRNA-seq data and finds that microbial reads are enriched in myeloid cells with proinflammatory transcriptional changes.

Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

The paper shows that lamin-A stabilizes the genome by protecting against nuclear rupture, DNA damage, and cell cycle arrest under mechanical stress.

Rescue of DNA damage in cells after constricted migration reveals bimodal mechano-regulation of cell cycle

The paper investigates DNA damage and cell cycle effects during constricted cell migration, finding a bimodal relationship between DNA damage and cell cycle regulation.

Universal antibiotic tolerance arising from antibiotic-triggered accumulation of redox metabolites

This study identifies a mechanism by which Pseudomonas aeruginosa develops antibiotic tolerance through antibiotic-induced accumulation of redox metabolites like pyocyanin.