Author

S. Malek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:Drosophila· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Dey· 2 shared S. Schmidt· 2 shared A. Ashworth· 1 shared A. Olivero· 1 shared C. L. Noland· 1 shared C. M. Rose· 1 shared D. Kirkpatrick· 1 shared D. Sampath· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

A. Dey

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

T. H. Pham, K. B. Pahuja, T. J. Hagenbeek, J. Zbieg, C. L. Noland, V. C. Pham, X. Yao, C. M. Rose, K. C. Browder, H.-J. Lee, M. Yu, M. Liang-Chu, S. E. Martin, E. Verschueren, J. Li, , A. Dey

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

bioRxiv · Oct 3, 2023 · PreprintCancer Biology

Impact of long-term storage on mid-infrared spectral patterns of serum and synovial fluid samples of dogs with osteoarthritis

S. Malek, F. Marini, J. T. McClure

This study evaluates how long-term storage affects mid-infrared spectral patterns of serum and synovial fluid from dogs with osteoarthritis, finding minimal impact on predictive model performance.

bioRxiv · Oct 2, 2022Biochemistry

RTK-dependent inducible degradation of mutant PI3K alpha drives GDC-0077 (Inavolisib) efficacy

K. Song, K. Edgar, E. Hanan, M. Hafner, J. Oeh, M. Merchant, D. Sampath, M. Nannini, R. Hong, L. Phu, W. Forrest, E. Stawiski, S. schmidt, N. Endres, J. Guan, , L. Friedman

The paper shows that GDC-0077 and taselisib degrade mutant PI3K alpha via HER2-dependent mechanisms, enhancing efficacy in PIK3CA-mutant breast cancer.

bioRxiv · May 12, 2021Cancer Biology