Author

S. Meaden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:bacteria (other)· 4 Approach:statistical model· 3 Research Focus:development & morphogenesis· 2 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Assay:metagenomics· 1

Frequent Co-Authors

E. R. Westra· 4 shared S. van Houte· 4 shared A. Biswas· 3 shared S. Gandon· 3 shared A. Buckling· 2 shared E. Westra· 2 shared H. Chabas· 2 shared L. J. Bartlett· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMicrobiology

E. R. Westra

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The evolution of host resistance to a virus is determined by resources, historical contingency, and time scale

E. Visher, H. Mahjoub, K. Soufi, N. Pascual, V. Hoang, L. J. Bartlett, K. E. Roberts, S. Meaden, M. Boots

This study shows that resource quality, historical contingency, and time scale influence the evolution of host resistance to a virus, affecting trade-offs and resistance strategies.

bioRxiv · Sep 8, 2022 · PreprintEvolutionary Biology

High viral abundance and low diversity are associated with increased CRISPR-Cas prevalence across microbial ecosystems

S. Meaden, A. Biswas, K. Arkhipova, S. E. Morales, B. E. Dutilh, E. R. Westra, P. C. Fineran

The paper examines the relationship between viral abundance and diversity and CRISPR-Cas prevalence across microbial ecosystems using metagenomic data.

bioRxiv · Jun 24, 2021Microbiology

Immune Lag Is a Major Cost of Prokaryotic Adaptive Immunity During Viral Outbreaks

J. L. Weissman, E. O. Alseth, S. Meaden, E. R. Westra, J. A. Fuhrman

The paper shows that immune lag during viral outbreaks is costly for prokaryotes, even for completely immune hosts, by analyzing host-virus dynamics.

bioRxiv · Sep 30, 2020Microbiology

Transient CRISPR immunity leads to coexistence with phages

S. Meaden, L. Capria, E. Alseth, A. Biswas, L. Lenzi, A. Buckling, S. van Houte, E. Westra

This study shows that CRISPR-based immunity in bacteria is transient, leading to stable coexistence with phages due to fitness costs and loss of spacers.

bioRxiv · Dec 19, 2019 · PreprintMicrobiology

The genomic basis of evolved virus resistance is dependent on environmental resources

K. Roberts, S. Meaden, S. Sharpe, S. Kay, T. Doyle, D. Wilson, L. J. Bartlett, S. Paterson, M. Boots

This study identifies genomic mechanisms of virus resistance in a lepidopteran pest, showing that resistance evolves differently under varying nutritional conditions and is linked to metabolic, immune, or cytoskeleton pathways.

bioRxiv · Jun 11, 2019 · PreprintEvolutionary Biology

Exploitation of the cooperative behaviours of anti-CRISPR phages

A. Chevallereau, S. Meaden, O. Fradet, M. Landsberger, A. Maestri, A. Biswas, S. Gandon, S. van Houte, E. Westra

This study shows Acr-negative phages benefit from Acr-positive phages by exploiting their immunosuppressive effects, with stronger Acr proteins providing greater fitness advantages.

bioRxiv · Mar 12, 2019Microbiology

Evolutionary emergence of infectious diseases in heterogeneous host populations

H. Chabas, S. Lion, A. Nicot, S. Meaden, S. van Houte, S. Moineau, L. M. Wahl, E. R. Westra, S. Gandon

This paper develops a theoretical model to predict pathogen emergence based on host population heterogeneity and validates it with experiments using bacteriophages and CRISPR-resistant bacteria.

bioRxiv · May 9, 2018Evolutionary Biology

Anti-CRISPR phages cooperate to overcome CRISPR-Cas immunity

M. Landsberger, S. Gandon, S. Meaden, H. Chabas, A. Buckling, E. R. Westra, S. van Houte

The paper shows that Acr-phages cooperate to overcome CRISPR-Cas immunity, with phage density and CRISPR resistance levels affecting their epidemiology.

bioRxiv · Mar 8, 2018Microbiology