Author

H. Chabas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:bacteria (other)· 4 Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. Bonhoeffer· 3 shared S. Gandon· 3 shared A. Nicot· 2 shared B. Siedentop· 2 shared E. R. Westra· 2 shared S. Meaden· 2 shared S. Moineau· 2 shared S. van Houte· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

S. Bonhoeffer

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Author profile →

7 papers

Recent·Most cited

Assessing the role of bacterial innate and adaptive immunity as barriers to conjugative plasmids

B. Siedentop, C. Losa-Mediavilla, R. D. Kouyos, S. Bonhoeffer, H. Chabas

This study models how bacterial innate and adaptive immunity affect plasmid spread, finding that immunity suppresses costly plasmids but not beneficial ones.

bioRxiv · Apr 12, 2024Microbiology

My host's enemy is my enemy: plasmids carrying CRISPR-Cas as a defence against phages

B. Siedentop, D. Ruegg, S. Bonhoeffer, H. Chabas

The paper develops a stochastic model to evaluate CRISPR-Cas plasmid-based anti-phage protection, showing it is robust except under specific parameter conditions where segregation loss enables phage outbreaks.

bioRxiv · Nov 1, 2023Microbiology

Extensive diversity and rapid turnover of phage defense repertoires in cheese-associated bacterial communities

V. Somerville, T. Schowing, H. Chabas, R. S. Schmidt, U. von Ah, R. Bruggmann, P. Engel

The paper analyzes defense mechanisms in cheese-associated bacterial communities, finding rapid turnover of phage defense repertoires and functional CRISPR spacers, but incomplete immunity.

bioRxiv · Apr 13, 2022Microbiology

Competition and coevolution drive the evolution and the diversification of CRISPR immunity

M. Guillemet, H. Chabas, A. Nicot, F. Gatchitch, E. Ortega-Abboud, C. Buus, L. Hindhede, G. M. Rousseau, T. Bataillon, S. Moineau, S. Gandon

This study shows coevolution between phages and bacteria drives CRISPR immunity diversification through negative-frequency-dependent selection and competitive asymmetries among host genotypes.

bioRxiv · Nov 12, 2021Microbiology

Epidemiological and evolutionary consequences of CRISPR-Cas reactivity

H. Chabas, V. Müller, S. Bonhoeffer, R. R. Regoes

This study shows that CRISPR-Cas reactivity determines phage extinction or survival during outbreaks and influences host fitness, with optimal reactivity balancing immune efficiency and autoimmunity costs.

bioRxiv · Jan 14, 2021 · PreprintMicrobiology

Evolutionary emergence of infectious diseases in heterogeneous host populations

H. Chabas, S. Lion, A. Nicot, S. Meaden, S. van Houte, S. Moineau, L. M. Wahl, E. R. Westra, S. Gandon

This paper develops a theoretical model to predict pathogen emergence based on host population heterogeneity and validates it with experiments using bacteriophages and CRISPR-resistant bacteria.

bioRxiv · May 9, 2018Evolutionary Biology

Anti-CRISPR phages cooperate to overcome CRISPR-Cas immunity

M. Landsberger, S. Gandon, S. Meaden, H. Chabas, A. Buckling, E. R. Westra, S. van Houte

The paper shows that Acr-phages cooperate to overcome CRISPR-Cas immunity, with phage density and CRISPR resistance levels affecting their epidemiology.

bioRxiv · Mar 8, 2018Microbiology