S. Moineau

HEPN-AbiV is an RNase in the antiphage system AbiV

This study identifies AbiV as an RNase in the bacterial antiphage system AbiV, revealing its structure, function, and mechanism of action.

Dairy practices select for thermostable endolysins in phages

The paper shows that dairy practices have selected for thermostable endolysins in phages infecting Streptococcus thermophilus, reducing endolysin diversity.

The influence of early life exposures on the infant gut virome

This study investigates how early life factors influence the gut virome composition in infants, identifying environmental exposures that shape viral communities and their potential metabolic impacts.

Building pyramids against the evolutionary emergence of pathogens

The paper compares three host resistance strategies to prevent pathogen evolutionary emergence, finding that pyramiding multiple defenses is more effective than mixing or combining strategies.

New Vista into Origins of Viruses from a Prototypic ssDNA Phage

The paper characterizes a lipid-containing ssDNA phage, {Phi}CjT23, and suggests it represents a model for the last common ancestor of ssDNA and dsDNA viruses in the Bamfordvirae.

CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice

This study shows that the CRISPR-Cas system of Eggerthella lenta provides limited phage immunity in vitro and in vivo, allowing coexistence of phage and bacteria in the gut.

Competition and coevolution drive the evolution and the diversification of CRISPR immunity

This study shows coevolution between phages and bacteria drives CRISPR immunity diversification through negative-frequency-dependent selection and competitive asymmetries among host genotypes.

Hundreds of viral families in the healthy infant gut

This study manually resolves viral dark matter in a large infant gut virome dataset, identifying over ten thousand viral species across 248 families and expanding bacteriophage taxonomy.

Analysis of viromes and microbiomes from pig fecal samples reveals that phages and prophages are not vectors of antibiotic resistance genes

The paper analyzes viromes and microbiomes from pig fecal samples to determine if phages or prophages carry antibiotic resistance genes, finding that ARGs are absent from active phages but present in prophages not detected in viromes.

Evolutionary emergence of infectious diseases in heterogeneous host populations

This paper develops a theoretical model to predict pathogen emergence based on host population heterogeneity and validates it with experiments using bacteriophages and CRISPR-resistant bacteria.

Immune Loss as a Driver of Coexistence During Host-Phage Coevolution

The paper shows that immune loss in bacteria can lead to stable coexistence with phages, contrasting with fitness tradeoffs, through theoretical and experimental analysis of CRISPR-Cas systems.