L. M. Wahl

Development of selective pyridopyrimidin-7(8H)-one-based Mammalian STE20-like (MST3/4) kinase inhibitors

This study develops selective MST3/4 kinase inhibitors and demonstrates their distinct cellular effects compared to MST1/2 inhibition.

Shifts in mutation bias promote mutators by altering the distribution of fitness effects

The paper shows that shifts in mutation bias can increase the probability of beneficial mutations, promoting the emergence of mutator strains.

Selection bias in mutation accumulation

This study quantifies selection bias in mutation accumulation experiments and proposes a correction method to improve estimates of mutation rates and fitness effects in microbes.

Mosaic vaccination: how distributing different vaccines across a population could improve epidemic control

This paper investigates mosaic vaccination, where different vaccines are distributed across a population, showing it can reduce infections and improve vaccine efficacy compared to uniform vaccination.

Shifts in mutation spectra enhance access to beneficial mutations

The paper shows that changing mutation spectra in E. coli increases beneficial mutations and reduces deleterious load, with simulations indicating that bias shifts are selectively favored.

Evolutionary emergence of infectious diseases in heterogeneous host populations

This paper develops a theoretical model to predict pathogen emergence based on host population heterogeneity and validates it with experiments using bacteriophages and CRISPR-resistant bacteria.