Author

S. Miersch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

G. K. Amarasinghe· 2 shared G. Novelli· 2 shared J. B. Case· 2 shared M. S. Diamond· 2 shared M. Ustav· 2 shared S. S. Sidhu· 2 shared A. Caruso· 1 shared A. S. Kim· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

G. K. Amarasinghe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants by Modular, Tetravalent, Bi-paratopic Antibodies

S. Miersch, R. Saberianfar, C. Chen, N. Sharma, G. K. Amarasinghe, F. Caccuri, A. Zani, A. Caruso, G. Novelli, S. S. Sidhu

This study develops a tetravalent antibody format that neutralizes SARS-CoV-2 variants with high potency and breadth, surpassing conventional bivalent antibodies.

bioRxiv · Nov 2, 2021Bioengineering

Synthetic antibodies neutralize SARS-CoV-2 infection of mammalian cells

S. Miersch, M. Ustav, Z. Li, J. B. Case, S. Ganaie, G. Matusali, F. Colavita, D. Lapa, M. R. Capobianchi, G. Novelli, J. B. Gupta, S. Jain, P. P. Pandolfi, M. S. Diamond, G. Amarasinghe, , S. S. Sidhu

The paper describes synthetic monoclonal antibodies that neutralize SARS-CoV-2 by binding to the spike protein and blocking ACE2 receptor interaction, showing potent antiviral activity.

bioRxiv · Jun 5, 2020 · PreprintBiochemistry

Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2.

J. B. Case, P. W. Rothlauf, R. E. Chen, Z. Liu, H. Zhao, A. S. Kim, L.-M. Bloyet, Q. Zeng, S. Tahan, L. Droit, M. X. G. Ilagan, M. A. Tartell, G. K. Amarasinghe, J. P. Henderson, S. Miersch, , S. P. J. Whelan

This study develops two neutralization assays for SARS-CoV-2 using VSV and a clinical isolate, showing high concordance between monoclonal, polyclonal antibodies, and ACE2-Fc in neutralizing activity.

bioRxiv · May 18, 2020Microbiology