Increased levels of the mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol
A. M. Schlagowski, K. Knöringer, S. Morlot, A. Sachez Vicente, F. Boos, N. Khalid, S. Ahmed, J. Schramm, L. M. Murschall, P. Haberkant, F. Stein, J. Riemer, B. Westermann, R. J. Braun, K. F. Winklhofer, , J. M. Herrmann
The paper shows that overexpressing Mia40 reduces toxic polyQ protein aggregates in yeast and human cells by competing for chaperone and proteasome resources.
bioRxiv · Feb 2, 2021Biochemistry