Author

B. R. Blazar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:non-human primate· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2

Frequent Co-Authors

L. S. Kean· 3 shared S. N. Furlan· 3 shared V. Tkachev· 3 shared A. Panoskaltsis-Mortari· 2 shared A. Yu· 2 shared C. McGuckin· 2 shared D. J. Hunt· 2 shared H. Zheng· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

L. S. Kean

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates

V. Tkachev, A. Vanderbeck, E. Perkey, S. N. Furlan, C. McGuckin, D. Gomez Atria, U. Gerdemann, X. Rui, J. Lane, D. J. Hunt, H. Zheng, L. Colonna, M. Hoffman, A. Yu, S. Kelly, , I. Maillard

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

bioRxiv · Apr 23, 2022 · PreprintImmunology

Restructuring of the Immune Contexture Improves Checkpoint Blockade Efficacy in Murine Lung Cancer

N. D. Ebelt, E. Zuniga, M. Marzagalli, V. Zamloot, B. R. Blazar, R. Salgia, E. R. Manuel

This study shows that altering the tumor immune landscape with shIDO-ST improves checkpoint blockade efficacy in murine lung cancer by enhancing antigen presentation and reducing suppressive immune cells.

bioRxiv · Oct 9, 2020 · PreprintCancer Biology

Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states.

V. Tkachev, J. Kaminski, E. L. Potter, S. N. Furlan, A. Yu, D. J. Hunt, C. McGuckin, H. Zheng, L. Colonna, U. Gerdemann, J. Carlson, M. Hoffman, J. Olvera, C. English, A. Baldessari, , L. S. Kean

The paper uses SIVS and scRNA-seq to analyze T cell infiltration and residency in the GI tract during aGVHD, identifying genes associated with tissue invasiveness and TRM programming.

bioRxiv · Jul 20, 2020 · PreprintImmunology

Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis

L. Almeida, A. Dhillon-LaBrooy, C. Castro, N. Ayele, J. Barthel, G. M. Carriche, M. Guderian, S. Lippens, S. Dennerlein, C. Hesse, B. Lambrecht, L. Schauser, B. R. Blazar, M. Kalesse, R. Mueller, , T. Sparwasser

bioRxiv · Nov 6, 2019Immunology

IL2 enhances ex-vivo expanded regulatory T cell persistence after adoptive transfer

S. N. Furlan, K. Singh, C. Lopez, V. Tkachev, D. Hunt, J. Hibbard, K. M. Betz, B. R. Blazar, C. Trapnell, L. S. Kean

This study shows that adding IL2 to rapamycin increases the persistence of ex-vivo expanded regulatory T cells in non-human primates, doubling their numbers in peripheral blood.

bioRxiv · Oct 15, 2019Immunology