J. Lane

B cell directed CAR-T cell therapy results in activation of CD8+ cytotoxic CAR-negative bystander T cells in both non-human primates and patients

The paper identifies a novel mechanism where CAR-T cell therapy activates CD8+ cytotoxic bystander T cells in non-human primates and patients, showing they can kill leukemic cells independently of TCR.

Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

Benefits of living closer to kin vary by genealogical relationship in a territorial mammal

The paper examines how proximity to different kin relationships affects survival and reproductive success in red squirrels, finding varying benefits depending on the genealogical relationship.

Using a Homeogram to Detect Sleep in Free-living Animals

This paper introduces a sleep detection method called a homeogram for accelerometer data from wild animals and applies it to red squirrels to identify unique sleep strategies in changing environments.

A heterodimeric SNX4:SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly

This study identifies the SNX4:SNX7 heterodimeric SNX-BAR complex as essential for ATG9A trafficking and autophagosome assembly in mammalian cells.

Stress activity is not predictive of coping style in North American red squirrels

The paper tests if physiological and behavioral stress responses are correlated in wild red squirrels and finds they are independent.

Individual variation in phenotypic plasticity of the stress axis

The paper investigates individual variation in endocrine plasticity of red squirrels in response to fluctuating conspecific density, finding significant individual differences in both mean endocrine phenotype and plasticity.

Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

This study identifies heparan sulfate as a critical regulator of G6b-B, showing it inhibits platelet and megakaryocyte function through Shp1/Shp2 signaling.

Seed masting causes fluctuations in optimum litter size and lag load in a seed predator

The paper examines how seed masting affects red squirrel litter sizes and fitness, finding increased selection for larger litters and a lag load during mast years.