Author

X. Rui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 2 Organism:non-human primate· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. McGuckin· 3 shared L. S. Kean· 3 shared U. Gerdemann· 3 shared V. Tkachev· 3 shared A. K. Shalek· 2 shared J. Kaminski· 2 shared J. Lane· 2 shared L. Cagnin· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

C. McGuckin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

B cell directed CAR-T cell therapy results in activation of CD8+ cytotoxic CAR-negative bystander T cells in both non-human primates and patients

J. Kaminski, R. A. Fleming, F. Alvarez-Calderon, C. McGuckin, E. E. Ho, F. Eng, X. Rui, P. Keskula, L. Cagnin, J. Charles, J. Zavistaski, S. P. Margossian, M. A. Kapadia, J. B. Rottman, J. Lane, , U. Gerdemann

The paper identifies a novel mechanism where CAR-T cell therapy activates CD8+ cytotoxic bystander T cells in non-human primates and patients, showing they can kill leukemic cells independently of TCR.

bioRxiv · Sep 28, 2023 · PreprintImmunology

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

P. Sarma, H.-J. Yoon, C. M. Carino, D. S., R. Banerjee, Y. Yun, J. Ji, K. Min, S. Pandey, H. Dwivedi-Agnihotri, X. Rui, Y. Cao, K. Kawakami, Y.-C. Chen, P. Kumari, , A. K. Shukla

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

bioRxiv · Jun 6, 2022Biochemistry

Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates

V. Tkachev, A. Vanderbeck, E. Perkey, S. N. Furlan, C. McGuckin, D. Gomez Atria, U. Gerdemann, X. Rui, J. Lane, D. J. Hunt, H. Zheng, L. Colonna, M. Hoffman, A. Yu, S. Kelly, , I. Maillard

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

bioRxiv · Apr 23, 2022 · PreprintImmunology

Identification and tracking of alloreactive T cell clones in Rhesus Macaques through the RM-scTCR-Seq platform.

U. Gerdemann, R. A. Fleming, J. Kaminski, C. McGuckin, X. Rui, J. F. Lane, P. Keskula, L. Cagnin, A. K. Shalek, V. Tkachev, L. S. Kean

The paper introduces RM-scTCR-Seq, a method for tracking T cell clones in Rhesus Macaques, and applies it to study GVHD.

bioRxiv · Oct 29, 2021Immunology