Author

S. N. Wai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Nadeem· 3 shared B. E. Uhlin· 3 shared K. Persson· 3 shared A. Alam· 2 shared E. Toh· 2 shared H. Pace· 2 shared M. Bally· 2 shared N. Zlatkov· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

A. Nadeem

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion

A. Nadeem, R. Nagampalli, E. Toh, A. Alam, S. L. Myint, T. V. Heidler, M. Dongre, N. Zlatkov, H. Pace, F. Bano, A. Sjostedt, M. Bally, B. E. Uhlin, S. N. Wai, K. Persson

This paper identifies a tripartite cytolytic toxin from Vibrio cholerae, showing that MakA/B/E proteins are secreted via flagella and form pores in membranes, contributing to bacterial virulence.

Proceedings of the National Academy of Sciences · Nov 19, 2021Peer-reviewedBiochemistry

Protein-lipid interaction at low pH induces oligomerisation of the MakA cytotoxin from Vibrio cholerae

A. Nadeem, A. Berg, H. Pace, A. Alam, E. Toh, J. Aden, N. Zlatkov, S. L. Myint, K. Persson, G. Gröbner, A. Sjöstedt, M. Bally, J. Barandun, B. E. Uhlin, S. N. Wai

This study shows that MakA, a Vibrio cholerae toxin, forms tube-like structures in acidic conditions through protein-lipid interactions, revealing a novel mechanism of membrane tubulation.

bioRxiv · Sep 10, 2021Cell Biology

The Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy

D. Corkery, A. Nadeem, K. M. Aung, A. Hassan, T. Liu, R. Cervantes-Rivera, A. H. Lystad, H. Wang, K. Persson, A. Puhar, A. Simonsen, B. E. Uhlin, S. N. Wai, Y. Wu

This study shows that Vibrio cholerae toxin MakA induces noncanonical autophagy, which inhibits canonical autophagy and immune responses like IL-1β secretion.

bioRxiv · Jul 7, 2020Cell Biology