J. Barandun

Nematocida displodere Mechanosensitive Ion Channel of Small Conductance 2 assembles into a unique 6-channel super-structure in vitro

This study determines the cryo-EM structure of MscS2 from Nematocida displodere, revealing its unique 6-channel super-structure and conservation of bacterial MscS features.

Ribosome clustering and surface layer reorganization in the microsporidian host-invasion apparatus.

The paper uses microscopy and cryo-electron tomography to study the structural changes in microsporidian polar tubes during host invasion and identifies ribosome clustering in the cargo-filled state.

A conserved ribosomal protein has entirely dissimilar structures in different organisms

The paper shows that the ribosomal protein msL1/msL2 has conserved location but entirely different structures across species, suggesting evolutionary fold switching driven by changes in rRNA binding sites.

Reductive evolution in the structure of the microsporidian proteasome.

This study presents cryo-EM structures of microsporidian proteasomes, revealing reductive evolution and structural changes during spore dormancy and germination.

Deep mutational scan of a drug efflux pump reveals its structure-function landscape

The paper uses deep mutational scanning to analyze the structure-function relationship of the EfrCD drug efflux pump, revealing how mutations affect drug efflux and identifying mutations that convert it into a drug importer.

Protein-lipid interaction at low pH induces oligomerisation of the MakA cytotoxin from Vibrio cholerae

This study shows that MakA, a Vibrio cholerae toxin, forms tube-like structures in acidic conditions through protein-lipid interactions, revealing a novel mechanism of membrane tubulation.

Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome.

The paper presents the cryo-EM structure of the microsporidian ribosome from Paranosema locustae, revealing a unique hibernation mechanism and structural features of rRNA reduction.

Modular assembly of the nucleolar large subunit processome

The paper determines cryo-EM structures of the nucleolar large subunit processome in different states, revealing how assembly factors prevent premature folding and enable distinct folding pathways.

The complete structure of the small subunit processome

The paper presents the cryo-EM structure of the yeast small subunit processome, revealing its atomic model and mechanisms preventing premature pseudoknot formation.