S. O'Connor

KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

This study identifies KAT5 as a regulator of G0-like states in glioblastoma, showing its role in suppressing non-dividing subpopulations and associating with worse patient outcomes.

AGO HITS-CLIP in Adipose Tissue Reveals miR-29 as a Post-Transcriptional Regulator of Leptin

The paper uses HITS-CLIP to identify miR-29 as a key post-transcriptional regulator of leptin in adipose tissue, with implications for obesity treatment.

Uncoupled activation and cyclisation in catmint reductive terpenoid biosynthesis

The paper identifies NEPS enzymes in catmint that catalyse stereoselective cyclisation of an enol intermediate into nepetalactol isomers, revealing uncoupled activation and cyclisation in reductive terpenoid biosynthesis.

Zika viruses of both African and Asian lineages cause fetal harm in a vertical transmission model

This study shows African ZIKV can cause fetal harm in a mouse model, challenging the idea that specific mutations are required for congenital Zika syndrome.

Pre-existing SIV Infection Increases Susceptibility to Tuberculosis in Mauritian Cynomolgus Macaques

This study shows that pre-existing SIV infection in macaques increases susceptibility to tuberculosis by impairing immune control of M.tb.

Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

This study compares ZIKV replication kinetics and tissue distribution in rhesus macaques infected via mosquito bite versus subcutaneous inoculation, finding delayed viral peak and restricted tissue distribution in mosquito-infected animals.

Identification of Iridoid Synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry

The paper identifies iridoid synthase enzymes in two Nepeta species and shows they do not determine nepetalactone stereochemistry, which is instead established later in the biosynthetic pathway.