Author

M. Kanke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1 Ecology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 6 Approach:experimental assay· 6 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Research Focus:gene regulatory network inference· 4 Organism:mouse· 4 Organism:human· 3 Approach:statistical model· 3

Frequent Co-Authors

P. Sethupathy· 7 shared C. G. Danko· 2 shared R. K. Ma· 2 shared A. B. Francisco· 1 shared A. Farghli· 1 shared A. Francisco· 1 shared A. J. Shumway· 1 shared A. Nakamura· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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7 shared papersCancer Biology

P. Sethupathy

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma

R. K. Ma, P.-Y. Tsai, A. R. Farghli, A. J. Shumway, M. Kanke, J. D. Gordan, T. Gujral, K. Vakili, M. Nukaya, L. Noetzli, S. Ronnekleiv-Kelly, W. Broom, J. Barrow, P. Sethupathy

This paper identifies LINC00473 as a downstream mediator of DNAJB1-PRKACA fusion in fibrolamellar carcinoma, showing it promotes tumor growth and alters mitochondrial function.

bioRxiv · Jun 2, 2023Cancer Biology

miR-29 is an important driver of aging-related phenotypes

V. Swahari, A. Nakamura, E. Hollville, Y.-H. Hung, M. Kanke, C. L. Kurtz, X. M. Caravia, S. He, J. Krishnamurthy, S. Kapoor, V. Prasad, C. Flowers, M. Beck, J. Baran-Gale, N. Sharpless, , M. Deshmukh

This study identifies miR-29 as a key driver of aging-related phenotypes by showing its upregulation in aging models and its ability to induce aging traits when overexpressed.

bioRxiv · Nov 29, 2022Physiology

Genome edited colorectal cancer organoid models reveal distinct microRNA activity patterns across different mutation profiles

J. W. Villanueva, L. Kwong, T. Han, S. A. Martinez, F. C. Pan, M. T. Shanahan, M. Kanke, S. Chen, L. E. Dow, C. G. Danko, P. Sethupathy

The paper uses genome-edited colorectal cancer organoids to identify microRNA expression patterns linked to specific mutation profiles and shows miR-24-3p's role in promoting cancer cell survival.

bioRxiv · Dec 13, 2021 · PreprintCancer Biology

Chemical, molecular, and single cell analysis reveal chondroitin sulfate proteoglycan aberrancy in fibrolamellar carcinoma

A. Francisco, J. Li, A. Farghli, M. Kanke, B. Shui, P. Soloway, Z. Wang, L. Reid, J. Liu, P. Sethupathy

This study identifies increased chondroitin sulfate proteoglycan levels in fibrolamellar carcinoma through gene expression, mass spectrometry, and single-cell sequencing.

bioRxiv · Dec 7, 2021 · PreprintCancer Biology

Ozone-induced changes in murine lung extracellular vesicle number and small RNA content

G. Smith, A. Tovar, M. Kanke, P. Sethupathy, S. Kelada

This study shows ozone exposure increases extracellular vesicle numbers and alters miRNA content in mouse lung BALF, with potential regulatory roles for specific miRNAs in airway macrophage responses.

bioRxiv · Jun 17, 2020 · PreprintPharmacology & Toxicology

Cladocopium community divergence in two Acropora coral hosts across multiple spatial scales

S. W. Davies, D. Wham, M. Kanke, M. Matz, K. Moreland

The paper quantifies Cladocopium algal symbiont community divergence in two Acropora coral hosts across spatial scales, finding structured symbiont communities within hosts and reefs but not between reefs on the same island.

bioRxiv · May 15, 2020Ecology

AGO HITS-CLIP in Adipose Tissue Reveals miR-29 as a Post-Transcriptional Regulator of Leptin

S. O'Connor, E. Murphy, S. K. Szwed, M. Kanke, F. Marchildon, R. B. Darnell, P. Sethupathy, P. Cohen

The paper uses HITS-CLIP to identify miR-29 as a key post-transcriptional regulator of leptin in adipose tissue, with implications for obesity treatment.

bioRxiv · Mar 13, 2020 · PreprintCell Biology

Hotspots of aberrant enhancer activity in fibrolamellar carcinoma reveal molecular mechanisms of oncogenesis and intrinsic drug resistance

T. A. Dinh, R. Sritharan, F. D. Smith, A. B. Francisco, R. K. Ma, R. P. Bunaciu, M. Kanke, C. G. Danko, A. P. Massa, J. D. Scott, P. Sethupathy

This study identifies aberrant enhancer activity in fibrolamellar carcinoma, revealing molecular mechanisms of oncogenesis and drug resistance, and suggests new therapeutic targets.

bioRxiv · Jan 18, 2020 · PreprintCancer Biology